Results 21 to 30 of about 60,176 (280)

EFFECT OF ERYTHROPOIETIN ON CYTOKINE PRODUCTION BY STEM CELLS

Медицинская иммунология, 2019
Erythropoietin (EPO) is mainly used to stimulate erythropoiesis. Its cytoprotective effects upon other cells of the human body and animals were recently shown, in particular, anti-apoptotic effect was observed.
A. P. Lykov, M. A. Surovtseva, O. V. Poveshchenko, N. A. Bondarenko, I. I. Kim, A. M. Chernyvski, A. V. Fomichev   +6 more
doaj   +1 more source

Structure of the Erythropoietin Receptor

Experimental Biology and Medicine, 1994
Despite extensive studies, the structure of the erythropoietin receptor remains little understood. cDNAs encoding the human and murine erythropoietin receptors have been cloned and the structure of these proteins is discussed. Although the proteins encoded by these cDNAs play key roles in erythropoietin binding and in erythropoietin signal transduction,
P, Mayeux, S, Pallu, S, Gobert, C, Lacombe, S, Gisselbrecht   +4 more
openaire   +2 more sources

Epoetin β pegol (continuous erythropoietin receptor activator, CERA) is another choice for the treatment of anemia in myelodysplastic syndrome: a case report

Journal of Medical Case Reports, 2017
Background In most patients, anemia is present when myelodysplastic syndrome is diagnosed. Although darbepoetin α is the first-choice supportive therapy for low-risk myelodysplastic syndrome, half of all patients develop a loss of response to darbepoetin
Tatsuyoshi Ikenoue, Hiroshi Naito, Tetsuya Kitamura, Hideki Hattori   +3 more
doaj   +1 more source

Definition of a family of tissue-protective cytokines using functional cluster analysis: a proof-of-concept study [PDF]

, 2014
The discovery of the tissue-protective activities of erythropoietin (EPO) has underlined the importance of some cytokines in tissue-protection, repair, and remodeling.
Annenkov, Alexander, Ermilov, Peter, Ghezzi, Pietro, Mengozzi, Manuela, Pearl, Frances   +4 more
core   +3 more sources

Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice.

PLoS ONE, 2019
Expression of hepcidin, the hormone regulating iron homeostasis, is increased by iron overload and decreased by accelerated erythropoiesis or iron deficiency.
Jana Frýdlová, Daniel W Rogalsky, Jaroslav Truksa, Emanuel Nečas, Martin Vokurka, Jan Krijt   +5 more
doaj   +1 more source

Possible erythropoietin pharmacotherapeutic targets on painful diabetic neuropathy in rats [PDF]

Anais da Academia Brasileira de Ciências
Erythropoietin is a renal cytokine involved in regulating hematopoiesis. Current evidence indicates that erythropoietin exerts pleiotropic effects in animal models.
SAMUEL SUAREZ-MENDEZ, DEYSI Y. BERMÚDEZ-OCAÑA   +1 more
doaj   +1 more source

Second-generation non-hematopoietic erythropoietin-derived peptide for neuroprotection

Redox Biology, 2022
Erythropoietin (EPO) is a well-known erythropoietic cytokine having a tissue-protective effect in various tissues against hypoxic stress, including the brain. Thus, its recombinants may function as neuroprotective compounds. However, despite considerable
Bongki Cho, Seung-Jun Yoo, So Yeon Kim, Chang-Hun Lee, Yun-Il Lee, Seong-Ryong Lee, Cheil Moon   +6 more
doaj   +1 more source

Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro [PDF]

, 1993
Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation.
Eckardt, Kai-Uwe, Kurtz, Armin, Pugh, C. W., Ratcliffe, P. J.   +3 more
core   +1 more source

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
doaj   +1 more source

Adding epoetin alfa to intense dose-dense adjuvant chemotherapy for breast cancer : randomized clinical trial [PDF]

, 2013
BACKGROUND: The AGO-ETC trial compared 5-year relapse-free survival of intense dose-dense (IDD) sequential chemotherapy with epirubicin (E), paclitaxel (T), and cyclophosphamide (C) (IDD-ETC) every 2 weeks vs conventional scheduled epirubicin ...
Bois, Andreas du, Hinke, Axel, Huober, Jens, Jackisch, Christian, Kreienberg, Rolf, Kuhn, Walther, Kurbacher, Christian, Lueck, Hans-Joachim, Moebus, Volker, Nitz, Ulrike, Runnebaum, Ingo B., Schneeweiss, Andreas, Thomssen, Christoph, Untch, Michael   +13 more
core   +1 more source