Upregulation of erythropoietin and erythropoietin receptor in castration-resistant progression of prostate cancer [PDF]
Asian Journal of Andrology, 2020 Hypoxia-induced erythropoietin signaling plays an important role in tumor growth and invasion. In the present study, we investigated the contribution of erythropoietin signaling pathway to castration-resistant prostate cancer and the development of a ...
Chen Ye +5 more
doaj +2 more sources
New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis [PDF]
Haematologica, 2018 Primary familial and congenital polycythemia is characterized by erythropoietin hypersensitivity of erythroid progenitors due to germline nonsense or frameshift mutations in the erythropoietin receptor gene.
Florence Pasquier +11 more
doaj +2 more sources
The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts [PDF]
Frontiers in Molecular Neuroscience, 2019 The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective erythropoietin receptor in locust neurons and emerged with the evolution of the eumetazoan nervous system.
Nina Hahn +8 more
doaj +2 more sources
New insights into erythropoietin and erythropoietin receptor in laryngeal cancer tissue. [PDF]
Medicine (Baltimore), 2021 Abstract To investigate whether laryngeal cancer cells express erythropoietin (Epo) and erythropoietin receptor (EpoR) and what is their possible relationship with clinical and pathological features of the tumor. We performed immunohistochemical analysis of Epo and EpoR expression on 78 tissue samples of invasive ...
Vukelic J +5 more
europepmc +4 more sources
Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma [PDF]
Cancer, 2002 AbstractBACKGROUNDErythropoietin (Epo), induced by hypoxia, controls the survival, proliferation, and differentiation of Epo receptor (EpoR)‐bearing erythroid progenitors and plays a role in the protection of neurons from hypoxic damage. Hypoxia in malignant disease is associated with invasion, metastasis, resistance to therapy, and selection for cells
Géza Acs +2 more
exaly +3 more sources
Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus
Early Human Development, 1998 Erythropoietin receptors (Epo-R) have been demonstrated on several nonhematopoietic cell types in animal models and in cell culture. Our objective was to determine the tissue distribution and cellular specificity of erythropoietin (Epo) and its receptor in the developing human fetus.The expression of Epo and Epo-R mRNA was ascertained by RT-PCR for ...
Sandra E Juul, Robert D Christensen
exaly +4 more sources
Calcium phosphate-based nanomedicine mediated CRISPR/Cas9 delivery for prostate cancer therapy
Frontiers in Bioengineering and Biotechnology, 2022 Introduction: Erythropoietin producing hepatocyte receptor A2 (EphA2) is widely presented in the tumor cells, closely related to tumor cell migration, not cell apoptosis and proliferation.
Chao-Gang Wei +7 more
doaj +1 more source
Expression of erythropoietin and erythropoietin receptor in peritoneal endometriosis [PDF]
Human Reproduction, 2003 Recent studies have indicated new physiological roles for erythropoietin (Epo) unrelated to erythropoiesis. We previously demonstrated that the Epo concentrations in peritoneal fluid from patients with stage I endometriosis were significantly higher than those with stages II, III and IV of the disease.
Sachiko, Matsuzaki +5 more
openaire +2 more sources
Symmetric signaling by an asymmetric 1 erythropoietin : 2 erythropoietin receptor complex [PDF]
, 2008 Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.Includes bibliographical references (p. 43-46).One erythropoietin molecule binds asymmetrically to two identical receptor monomers via erythropoietin site 1 ...
Zhang, Yingxin
core +4 more sources
Frontiers in Immunology, 2021 Endogenous mechanisms underlying bacterial infection resolution are essential for the development of novel therapies for the treatment of inflammation caused by infection without unwanted side effects.
Feihong Liang +10 more
doaj +1 more source