Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects. [PDF]
PLoS ONE, 2012 BackgroundErythropoietin receptors have been identified in human skeletal muscle tissue, but downstream signal transduction has not been investigated.
Britt Christensen +9 more
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Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care [PDF]
, 2012 Author can archive publisher's pdf. Free via Creative Commons: CC-BENCHTOBEDSIDE-2.0.
Nandra, KK, Patel, NSA, Thiemermann, C
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Low oxygen tension primes aortic endothelial cells to the reparative effect of tissue-protective cytokines [PDF]
, 2015 Erythropoietin (EPO) has both erythropoietic and tissue-protective properties. The EPO analogues carbamylated EPO (CEPO) and pyroglutamate helix B surface peptide (pHBSP) lack the erythropoietic activity of EPO but retain the tissue-protective properties
A Anagnostou +57 more
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Disease Models & Mechanisms, 2013 SUMMARY There is limited evidence that the tissue-protective effects of erythropoietin are mediated by a heterocomplex of the erythropoietin receptor and the β-common receptor (‘tissue-protective receptor’), which is pharmacologically distinct from the ...
Areeg I. Khan +8 more
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Erythropoietin receptor and hematological disease [PDF]
American Journal of Hematology, 1999 This review will discuss evidence for the role of the erythropoietin (Epo) receptor in the development of erythrocytosis and other hematological disorders. The possible causative role of mutations of other genes in the pathogenesis of idiopathic erythrocytosis will be considered. Polycythemia vera (PV) is a myeloproliferative disorder that is caused by
McMullin, Mary Frances, Percy, M.J.
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Scientific Reports, 2022 Cytokine receptor-like factor 3 (CRLF3) is a conserved but largely uncharacterized orphan cytokine receptor of eumetazoan animals. CRLF3-mediated neuroprotection in insects can be stimulated with human erythropoietin.
Debbra Y. Knorr +6 more
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Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]
, 2003 Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber +36 more
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Glycosylation of the murine erythropoietin receptor [PDF]
FEBS Letters, 1990 Murine erythropoietin‐responsive Rauscher Red 5‐1.5 cells were used to determine the contribution of glycosylation to the size and function of the erythropoietin receptor. The half life of the receptors was determined to be 4 h. The number of receptors was not significantly decreased in cells treated for 48 h with inhibitors of glycosylation ...
Mayeux, P. +3 more
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Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease. [PDF]
PLoS ONE, 2010 Erythropoietin is a growth factor commonly used to manage anemia in patients with chronic kidney disease. A significant clinical challenge is relative resistance to erythropoietin, which leads to use of successively higher erythropoietin doses, failure ...
Eliyahu V Khankin +5 more
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Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
, 2014 Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
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