Results 131 to 140 of about 137,570 (250)

Targeting lysine methyltransferase 2C deficiency: New frontiers in breast cancer therapy and prognosis

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This graphical abstract illustrates the role of KMT2C loss‐of‐function in promoting breast cancer progression and therapeutic vulnerability. KMT2C deficiency drives tumor heterogeneity, metastasis, and therapy resistance by activating oncogenic pathways such as IFNγEMT/MET and MAPK/ERKRAS/PI3K/AKT/mTOR, along with epigenetic remodeling via the ...
Shuangmei Tong, Qiu Wang, Yun Chen, Zunjie Bo, Ya Zhang, Yan Liu   +5 more
wiley   +1 more source

Integrative Omics Analysis Reveals the Potential Value of CEACAM6 in Pan‐Gastrointestinal Cancers

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Expression of CEACAM6 in spatial transcriptomic of colorectal cancer with liver metastases. (A) Predicted cell types mapping on colorectal cancer tissue slice; (B) Spatial distribution of CEACAM6; (C) Spatial distribution of malignant region, mixed region and normal region; (D) The difference expression of CEACAM6 in malignant region, mixed region and ...
Liying Jin, Changjuan Tao, Zhiyong Pan, Peng Zhang   +3 more
wiley   +1 more source

Radiogenomics: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 2, February 2026.
Radiogenomics links imaging phenotypes with genetic variations, offering potential for comprehensive understanding, cost‐effective diagnosis, and prognosis prediction to advance personalized medicine. However, its clinical application remains limited by several challenges.
Xinyu Zhang, Qingpei Lai, Jin Cao, Jerry Chi Fung Ching, Xinzhi Teng, Jiang Zhang, Shara Wee Yee Lee, Ge Ren, Jing Cai   +8 more
wiley   +1 more source

X-ray photoelectron spectroscopy study of nickel and nickel-base alloy surface alterations in simulated hot corrosion conditions with emphasis on eventual application to turbine blade corrosion [PDF]

Research on the high temperature oxidation and Na2SO4 induced hot corrosion of some nickel base superalloys was accomplished by using ESCA to determine the surface composition of the oxidized or corroded samples.
Mateescu, G. D., Smith, S. R.
core   +1 more source

Unveiling a BRAF Signature Proficient in Accurately Capturing Oncogenic Activity and Guiding Prognostic Prediction Across Multiple Cancers

MedComm, Volume 7, Issue 2, February 2026.
The BRAF25 meta‐signature effectively captures BRAF‐driven oncogenic activity. By enabling precise patient stratification with distinct mutation profiles, BRAF25 identifies BRAF‐active tumor subtypes and provides superior prognostic value compared with mutation status alone.
Kaidi Yang, Shihui Fu, Jingbing Liang, Lijuan Ding, Junhao You, Fang Li, Ye Yuan, Xiu‐Wu Bian   +7 more
wiley   +1 more source

Integrative Analysis of Cytotoxic Lymphocytes‐Mediated Tumour Killing Related Genes Reveals LDHA as a Novel Glioblastoma Therapeutic Target

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT Glioblastoma (GBM) features profound immunosuppression and metabolic reprogramming that undermine immunotherapy. We sought biomarkers that capture cytotoxic lymphocyte activity and nominate tractable targets. Using TCGA, we quantified NK/CD8+ T‐cell infiltration (CIBERSORTx), identified differentially expressed genes and derived a three‐gene ...
Shaojie Yu, Xudong Li, Ji Wu, Minjie Wang, Zihan Gong, Baowen Zhang, Haojun Shi, Xuan Wang, Wei Xiang   +8 more
wiley   +1 more source

Clinical significance and immune microenvironment association of cuproptosis‐related genes in pan‐cancer

Experimental Physiology, Volume 111, Issue 2, Page 539-555, 1 February 2026.
Abstract Recent studies highlight the important roles of cuproptosis in cancer cells. However, the roles of the cuproptosis‐related genes (CRGs) in different cancers are still not fully understood. Comprehensive analysis was performed using open‐source bioinformatic platforms to disclose the expression profiles, prognostic significance, genomic and ...
Xinyu Ge, Kaijing Wang, Tian Zhao, Jinyi Wang, Jie Liu, Zhengliang Sun, Zhengjun Chai, Wen Zhang, Chengbao Li, Yan Xu, Guohan Chen   +10 more
wiley   +1 more source

XPS study of the effect of hydrocarbon contamination on polytetrafluoroethylene (teflon) exposed to atomic oxygen [PDF]

The presence of hydrocarbon contamination on the surface of polytetrafluoroethylene (PTFE) markedly affects the oxygen uptake, and hence the wettability, of this polymer when exposed to an oxygen plasma.
Cormia, Robert D., Golub, Morton A., Wydeven, Theodore   +2 more
core   +1 more source

A review of tin oxide-based catalytic systems: Preparation, characterization and catalytic behavior [PDF]

This paper reviews the important aspects of the preparation, characterization and catalytic behavior of tin oxide-based catalytic systems including doped tin oxide, mixed oxides which contain tin oxide, Pt supported on tin oxide and Pt/Sn supported on ...
Hoflund, Gar B.
core   +1 more source

Identification of MAPK12 as a Prognostic Biomarker for Esophageal Carcinoma Using Bioinformatics and Machine Learning. [PDF]

Biomed Res Int
Gu S, Yan X, Chen S, Dong Z, Li X, Ye C, Zhao C, Yuan H, Sun X, Zhao W, Zhang P.   +10 more
europepmc   +1 more source