Results 101 to 110 of about 919 (250)

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Potential Impacts of Low Flows on Fish Foodscapes and Production in a Braided River

River Research and Applications, EarlyView.
ABSTRACT Changes in river discharge affect the physical composition and connectivity of habitats which, in turn, may shape the spatial distribution of fish food abundance, accessibility and quality—the ‘foodscape’—of river ecosystems. However, the influence of river flows on fish foodscapes has received very little attention from scientists. We studied
Rick J. Stoffels, Richard S. A. White, Gergely T. Torok, Richard J. Measures, Kristy L. Hogsden, Alex F. Rose, Paul W. Lambert, Jaret P. Bilewitch, S. Elizabeth Graham, Lisa Smith, Amber R. Brooks, Brian J. Smith   +11 more
wiley   +1 more source

Deep learning‐based super‐resolution reconstruction and improved YOLOv9 for efficient benthos detection: a case study at Lake Hamana, Japan

Remote Sensing in Ecology and Conservation, EarlyView.
This study presents a UAV‐based framework that integrates deep learning‐based super‐resolution reconstruction and an enhanced YOLO detector to improve centimetre‐scale benthic organism monitoring. Using hermit crabs in Lake Hamana, a coastal lagoon in Japan, as a case study, the method substantially enhanced small‐object detection performance ...
Fan Zhao, Bangzhang Ma, Dianhan Xi, Jiaqi Wang, Yijia Chen, Yongying Liu, Xinlei Shao, Mowen Zhang, Guocheng Zhang, Jundong Chen, Katsunori Mizuno   +10 more
wiley   +1 more source

Preferential Solvation by Trifluoroethanol Drives α-Helical Folding in the Disordered S2 Region of the Escargot Protein. [PDF]

Chemphyschem
Piccoli V, Pereira AF, Rivillas-Acevedo L, Pastor N, Peláez-Aguilar ÁE, Martínez L.   +5 more
europepmc   +1 more source

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Drosophila AHR limits tumor growth and stem cell proliferation in the intestine

, 2023
Tsai M, Sun J, Alexandre C, Shapiro M, Franchet A, Li Y, Gould AP, Vincent J, Stockinger B, Diny NL.   +9 more
europepmc   +1 more source

Oxidative Damage, Energy Imbalance, and Behavioral Disruptions in Girardia tigrina Exposed to Treated Sewage Effluents

Environmental Toxicology, EarlyView.
ABSTRACT This study assessed the ecotoxicological effects of treated sewage on the freshwater planarian Girardia tigrina, integrating biochemical, energetic, and behavioral biomarkers. Planarians were exposed for 48 h to different concentrations of treated sewage (12.5%, 25%, 50%, and 100%) and compared to controls using commercial water and water from
Renata M. P. Freitas, Pedro H. Carvalho, Daniela de Melo e Silva, Carlos Gravato   +3 more
wiley   +1 more source

Non-gonadal PIWIL1/Aubergine drives regenerative and tumorigenic stem cell proliferation and tumorigenesis in the intestine. [PDF]

Cell Rep
Bellec K, Carroll LR, Pennel KAF, Tian Y, Yu Y, Akan AB, Billard CV, Doleschall N, Cameron AR, Herédia F, Gontijo AM, Ochocka-Fox AM, Blackmur JP, Din FVN, Dunlop MG, Edwards J, Myant K, Hayashi R, Cordero JB.   +18 more
europepmc   +1 more source