Results 151 to 160 of about 919 (250)

Polycomb-mediated silencing of miR-8 is required for maintenance of intestinal stemness in Drosophila melanogaster. [PDF]

Nat Commun
Veneti Z, Fasoulaki V, Kalavros N, Vlachos IS, Delidakis C, Eliopoulos AG.   +5 more
europepmc   +1 more source

Holocene shoreline displacement and the impact of the Storegga tsunami on Hinnøya, northern Norway

Boreas, EarlyView.
The Holocene relative sea‐level (RSL) history of Norway's largest island, Hinnøya, has been investigated in detail, using sediment records from 25 isolation basins. The sediments were analysed for macrofossil and phytoplankton content, which served as the basis for identifying marine–lacustrine transitions, that is isolation contacts. Terrestrial plant
Anders Romundset, Kristian Vasskog, Martin Buran, Svein Olaf Dahl, Fredrik Høgaas, Mara Sternberg   +5 more
wiley   +1 more source

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer. [PDF]

Oncogene
Reissland M, Hartmann O, Tauch S, Bugter JM, Prieto-Garcia C, Schulte C, Loebbert S, Solvie D, Bitman-Lotan E, Narain A, Jacomin AC, Schuelein-Voelk C, Fuss CT, Pahor N, Ade C, Buck V, Potente M, Li V, Beliu G, Wiegering A, Grossmann T, Eilers M, Wolf E, Maric H, Rosenfeldt M, Maurice MM, Dikic I, Gallant P, Orian A, Diefenbacher ME.   +29 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Versatile Magneto-Dielectric Response of Epitaxial Thin Films of the High Entropy Oxide Perovskite Nd(Cr_0.2Mn_0.2Fe_0.2Co_0.2Ni_0.2)O₃. [PDF]

Adv Mater
Capu R, Thompson R, Rischau CW, Cantarino MR, Marsik P, Bud'ko SL, Biškup N, Varela M, Pashkevich YG, Orel SM, Prokscha T, Suter A, Zhao J, Oji U, Bonura M, Bencok P, Salman Z, Gariglio S, Bernhard C, Sarkar S.   +19 more
europepmc   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, EarlyView.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. [PDF]

Nat Commun
Petsakou A, Filine E, Li M, Chen Y, Zheng A, Perrimon N.   +5 more
europepmc   +1 more source

Michael Krebber : les escargots ridiculisés [PDF]

Critique d’art, 2012
openaire   +1 more source

Decreased Expression of FAT4 Promotes Multiple Myeloma Proliferation and Migration by Targeting the Hippo/YAP Pathway

Cancer Science, EarlyView.
This study provides the first comprehensive characterization of the functional impact, and mechanistic role of FAT4 in MM. Our findings highlight the tumor‐suppressive role of FAT4 in MM and uncover a novel mechanism by which FAT4 regulates the Hippo/YAP pathway.
Lina Zhang, Na Shen, Xin Cheng, Qinglin Shi, Lijuan Chen, Xuxing Shen   +5 more
wiley   +1 more source

An endogenous retroviral element co-opts an upstream regulatory sequence to achieve somatic expression and mobility. [PDF]

Nucleic Acids Res
Rubanova N, Singh D, Barolle L, Chalvet F, Netter S, Poidevin M, Servant N, Bardin AJ, Siudeja K.   +8 more
europepmc   +1 more source