Results 161 to 170 of about 919 (250)

Epithelial YPEL3 Modulates CD8+ T‐Cell Infiltration and Tumor Progression Through CREB1–CXCL16 Signaling in HNSCC

Cancer Science, EarlyView.
YPEL3 functions as a tumor suppressor in HNSCC by inhibiting tumor progression and promoting apoptosis. Mechanistically, it enhances epithelial–immune crosstalk through the CREB1‐mediated CXCL16–CXCR6 axis, facilitating CD8+ T‐cell infiltration and highlighting its potential as a prognostic biomarker and immunotherapy target.
Yalun Li, Yumei Li, Caiyu Sun, Congxian Lu, Gang Chen, Tianshu Zhou, Bei Zhang, Xicheng Song   +7 more
wiley   +1 more source

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

Structural basis for the substrate specificity of Helix pomatia AMP deaminase and a chimeric ADGF adenosine deaminase. [PDF]

J Biol Chem
Kaur G, Horton JR, Tzertzinis G, Zhou J, Schildkraut I, Cheng X.   +5 more
europepmc   +1 more source

Mating induces switch from hormone-dependent to hormone-independent steroid receptor-mediated growth in Drosophila secondary cells. [PDF]

PLoS Biol, 2019
Leiblich A, Hellberg JEEU, Sekar A, Gandy C, Mendes CC, Redhai S, Mason J, Wainwright M, Marie P, Goberdhan DCI, Hamdy FC, Wilson C.   +11 more
europepmc   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis. [PDF]

Cell Prolif
Kong R, Zhao H, Li J, Ma Y, Li N, Shi L, Li Z.   +6 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity. [PDF]

Dis Model Mech
Lacarrière-Keïta C, Nassari S, Boutet J, Gaudreault V, Jean S.   +4 more
europepmc   +1 more source

Strategic conservation prioritization through creating and updating the regional species of greatest conservation need list in the northeastern United States

Conservation Science and Practice, EarlyView.
Biodiversity is declining globally, underscoring the need for conservation strategies informed by regional expertise. In the northeastern United States, 14 state wildlife agencies and taxonomic experts developed the Regional Species of Greatest Conservation Need (RSGCN) list, revealing that global and national datasets captured only ~55% of regionally ...
Melissa D. Starking, Tracy Monegan Rice, Karen Terwilliger, Donovan Drummey, Mack Frantz, Catherine D. Haffner, Brian Hess, Lisa Holst, Michael Marchand, Kevin R. Burgio   +9 more
wiley   +1 more source

An Enhanced Rehabilitation Approach for a Patient With Leukemia and Severe Intensive Care Unit-Acquired Weakness Following Critical Pneumonia. [PDF]

Cureus
Onji M, Ohta T, Kakizoe S.
europepmc   +1 more source