Results 51 to 60 of about 4,520 (272)
Seizure Suppression by Gain-of-Function escargot Mutations [PDF]
Genetics, 2005 Abstract Suppressor mutations provide potentially powerful tools for examining mechanisms underlying neurological disorders and identifying novel targets for pharmacological intervention. Here we describe mutations that suppress seizures in a Drosophila model of human epilepsy.
Daria S, Hekmat-Scafe +2 more
openaire +2 more sources
Advanced Science, EarlyView.A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du +18 more
wiley +1 more source
Frontiers in Genetics, 2018 In recent years, several genes involved in complex neuron specification networks have been shown to control life span. However, information on these genes is scattered, and studies to discover new neuronal genes and gene cascades contributing to life ...
Alexander V. Symonenko +5 more
doaj +1 more source
THE ROLE OF SMALL TOWNS IN LOCAL PLACE MAKING [PDF]
, 2016 Self-promotion and reinterpretation of local identity is becoming increasingly important in rural communities. Local identity building is succeeded very differently by rural municipalities and regions.
Csurgó, Bernadett, Megyesi, Boldizsár
core +2 more sources
Advanced Science, EarlyView.We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li +10 more
wiley +1 more source
Lutte contre les gastéropodes : tests de produits biologiques alternatifs au métaldéhyde : compte-rendu d'essai 2006 [PDF]
, 2007 Cet essai a pour objectif de définir si l'utilisation de doses réduites d'orthophosphate (limitant ainsi les coûts) limite l'efficacité du produit de façon rédhibitoire, pour différents niveaux de populations d'escargots.
Lambion, Jérôme, Mounier, Jean-Michel
core
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Influence des escargots d'eau (Pomacea canaliculata) sur la persistance du virus H5N1 dans l'environnement [PDF]
, 2010 La grippe aviaire à H5N1 a causé de nombreuses épidémies à partir de 2004 en Asie du Sud-est. La Thaïlande, l'un des plus gros producteurs de volailles dans le monde, a été sévèrement touchée par ces différentes épidémies.
Gonzalez, Daniel
core
Sur deux neveux d'Eisenstein [PDF]
, 1988 Artavazd Péléchian et Serghei Paradjanov, réalisateurs arméniens contemporains, ont tous deux été influencés par l'esthétique d'Eisenstein, héritage qu'ils ont réinterprété, chacun à sa façon, comme ils ont réinterprété celui de Vertov.
Amengual, Barthélemy
core +1 more source
Advanced Science, EarlyView.Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin +12 more
wiley +1 more source