ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner [PDF]
BMC Cancer, 2023 Background The establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) is involved in the development of multiple malignancies. However, its role in hypopharyngeal carcinoma (HPC) progression remains uncharacterized.
Juan Hu +12 more
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Complex cerebrovascular diseases in Roberts syndrome caused by novel biallelic ESCO2 variations [PDF]
Molecular Genetics & Genomic Medicine, 2023 Objective Roberts syndrome (RBS), also known as Roberts‐SC phocomelia syndrome, is a rare autosomal recessive developmental disorder caused by mutations in the ESCO2 gene.
Shuang He +4 more
doaj +6 more sources
Case report: The evolving phenotype of ESCO2 spectrum disorder in a 15-year-old Malaysian child [PDF]
Frontiers in Genetics, 2023 ESCO2 spectrum disorder is an autosomal recessive developmental disorder characterized by growth retardation, symmetrical mesomelic limb malformation, and distinctive facies with microcephaly, with a wide phenotypic continuum that ranges from Roberts ...
Sok-Kun Tae +4 more
doaj +4 more sources
ESCO2 inhibition induces cell cycle arrest and apoptosis in breast cancer via the P53-CDK1 axis and the BAX/Bcl2/caspase signaling cascade [PDF]
Frontiers in OncologyBackgroundBreast cancer is a major threat to women’s health, and dysregulation of the cell cycle is a critical driver of its progression. ESCO2, a potential key regulator of the cell cycle, is implicated in cancer development; however, its specific role ...
Pingchuan Li +4 more
doaj +4 more sources
The expression of establishment of cohesion 1 homolog 2 (ESCO2) in tumor cells and its research progress as a therapeutic target [PDF]
European Journal of Medical ResearchThe initiation and progression of tumors are closely linked to aberrant regulation of multiple genes. Among these genes, sister chromatid cohesion acetyltransferase 2 (ESCO2) has emerged as an important target in cancer research. ESCO2 exhibits complex
Chunmei Lu, Hanchi Wu, Huiyu Wang
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ESCO2 inhibits tumor metastasis via transcriptionally repressing MMP2 in colorectal cancer
Cancer Management and Research, 2018 Xiong-Bo Guo,1,* Bin Huang,1,* Ying-Hua Pan,2 Shu-Guang Su,3 Yan Li3 1Department of General Surgery, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, China; 2Department of Rheumatology, The Third Affiliated Hospital of ...
Guo XB, Huang B, Pan YH, Su SG, Li Y
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Long noncoding RNA ZFPM2‐AS1 regulates renal cell carcinoma progression via miR‐130a‐3p/ESCO2 [PDF]
Kaohsiung Journal of Medical Sciences, 2022 Previous studies reported that long noncoding RNA (lncRNA) ZFPM2‐AS1 is upregulated in renal cell carcinoma (RCC). However, the biological role of lncRNA ZFPM2‐AS1 in RCC has not been explored.
Gang Zhang +4 more
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Cohesin mediates Esco2-dependent transcriptional regulation in a zebrafish regenerating fin model of Roberts Syndrome [PDF]
Biology Open, 2017 Robert syndrome (RBS) and Cornelia de Lange syndrome (CdLS) are human developmental disorders characterized by craniofacial deformities, limb malformation and mental retardation.
Rajeswari Banerji +2 more
doaj +4 more sources
ESCO2 promotes the proliferation of hepatocellular carcinoma through the PI3K/AKT/ mTOR signaling pathway. [PDF]
J CancerBackground: Establishment of sister chromatid cohesion N-Acetyltransferase 2 (ESCO2) is a gene implicated in the establishment of sister chromatid cohesion (SCC) and cell proliferation. We aimed to explore how ESCO2 affects the proliferation of hepatocellular carcinoma (HCC).
Chen D +5 more
europepmc +4 more sources
Limb reduction in an Esco2 cohesinopathy mouse model is mediated by p53-dependent apoptosis and vascular disruption [PDF]
Nature CommunicationsRoberts syndrome (RBS) is an autosomal recessive disorder with profound growth deficiency and limb reduction caused by ESCO2 loss-of-function variants.
Arielle S. Strasser +8 more
doaj +4 more sources