Results 141 to 149 of about 1,393 (149)
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Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis
Clinical Rheumatology, 2022Rheumatoid arthritis (RA) is an autoimmune condition that causes progressive inflammation. It seems that alternations in epigenetic modifications contribute to RA development. The present study aimed to assess the expression pattern of K (lysine) acetyltransferase 1 (KAT1; HAT1) and lysine acetyltransferase 2B (KAT2B; PCAF), and the establishment of ...
Alaleh Ghasemi +9 more
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Esco2 promotes neuronal differentiation by repressing Notch signaling
Cellular Signalling, 2011Esco2 is an acetyltransferase that is required for the establishment of sister chromatid cohesion. Roberts-SC phocomelia (RBS) syndrome caused by the mutations of Esco2 gene, is an autosomal recessive development disorder characterized by growth retardation, limb reduction and craniofacial abnormalities including cleft lip and palate.
Young-Eun, Leem +8 more
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Esco2 is a novel corepressor that associates with various chromatin modifying enzymes
Biochemical and Biophysical Research Communications, 2008Accurate chromosome segregation during cell division requires that sister chromatids are kept together by cohesin complex until anaphase, when the chromatids separate and distribute to the two daughter cells. Esco2 is an acetyltransferase that is required for the establishment of sister chromatid cohesion during S phase.
Beom-Jun, Kim +9 more
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2008
Abstract Roberts syndrome (RBS) or SC phocomelia syndrome (OMIM 286300 and 269000) is a rare autosomal recessive condition characterized by preand postnatal growth retardation, symmetric and mesomelic limb reductions, and craniofacial abnormalities.
Hugo Vega +2 more
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Abstract Roberts syndrome (RBS) or SC phocomelia syndrome (OMIM 286300 and 269000) is a rare autosomal recessive condition characterized by preand postnatal growth retardation, symmetric and mesomelic limb reductions, and craniofacial abnormalities.
Hugo Vega +2 more
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ESCO2 knockdown inhibits cell proliferation and induces apoptosis in human gastric cancer cells
Biochemical and Biophysical Research Communications, 2018Establishment of cohesion 1 homolog 2 (ESCO2), an essential gene for cohesion regulation and genomic stability, has not been studied in human gastric cancer (GC). We found that ESCO2 knockdown in human GC cell lines dramatically inhibited cell proliferation and induced cell apoptosis in vitro and suppressed tumor xenograft development in vivo ...
Hongmei, Chen +6 more
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Understanding the Mechanism of Recruitment of Esco1 and Esco2 to Cohesin
2023For cells to faithfully transmit their genetic material to the daughter cells, chromosome segregation during mitosis must be accurately and timely executed. One way to ensure this is by keeping the duplicated chromosomes (sister chromatids) together until they are separated at the metaphase-to-anaphase transition. Sister chromatids are held together by
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Localization and regulation of murine Esco2 during male and female meiosis.
Biology of reproduction, 2013Meiosis is essential for generation of healthy gametes in both sexes and involves recombination and segregation of homologous chromosomes to produce haploid gametes. The initiation of meiosis in both sexes relies upon retinoic acid (RA) (Griswold MD, Hogarth CA, Bowles J, Koopman P. Initiating Meiosis: The Case for Retinoic Acid.
EVANS, Elizabeth B +5 more
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A NOVEL FRAMESHIFT MUTATION IN ESCO2 GENE CAUSE ROBERTS SYNDROME: CASE PRESENTATION
2019…
Mengen, Eda +3 more
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