Results 11 to 20 of about 1,393 (149)

ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation [PDF]

Journal of Experimental & Clinical Cancer Research, 2020
Abstract Background: Emerging evidence indicates that metabolism reprogramming and abnormal acetylation modification play an important role in lung adenocarcinoma (LUAD) progression, although the mechanism is largely unknown. Methods: Here, we used three public databases (Oncomine, Gene Expression Omnibus [GEO], The Cancer Genome Atlas [TCGA ...
Hui-er Zhu, Tao Li, Shengnan Shi, Dexiong Chen, Weiping Chen, Hui Chen   +5 more
openalex   +5 more sources

ESCO2's Oncogenic Role in Human Tumors: A Pan-Cancer Analysis and Experimental Validation [PDF]

BMC Cancer, 2023
Abstract Purpose: Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2 (ESCO2) is a member of histone acetyltransferases. ESCO2 is involved in the mitotic S-phase adhesins acetylation and is responsible for bridging two sister chromatids. However, present ESCO2 cancer research is limited to a few cancers.
Yue Huang, Dapeng Chen, Yi Bai, Yamin Zhang, Zhiwen Zheng, Qingfeng Fu, Bocun Yi, Yuchen Jiang, Jianqiang Zhu, Zhihong Zhang   +9 more
openalex   +4 more sources

ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Background Emerging evidence indicates that metabolism reprogramming and abnormal acetylation modification play an important role in lung adenocarcinoma (LUAD) progression, although the mechanism is largely unknown.
Hui-er Zhu, Tao Li, Shengnan Shi, De-xiong Chen, Weiping Chen, Hui Chen   +5 more
doaj   +2 more sources

A zebrafish model of Roberts syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle.

PLoS ONE, 2011
The human developmental diseases Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS) are both caused by mutations in proteins responsible for sister chromatid cohesion.
Maren Mönnich, Zoë Kuriger, Cristin G Print, Julia A Horsfield   +3 more
doaj   +2 more sources

Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2 [PDF]

Current Biology, 2015
Sister chromatid cohesion is mediated by cohesin and is essential for accurate chromosome segregation. The cohesin subunits SMC1, SMC3, and Rad21 form a tripartite ring within which sister chromatids are thought to be entrapped. This event requires the acetylation of SMC3 and the association of sororin with cohesin by the acetyltransferases Esco1 and ...
Masashi Minamino, Mai Ishibashi, Ryuichiro Nakato, Kazuhiro Akiyama, Hiroshi Tanaka, Yuki Kato, Lumi Negishi, Toru Hirota, Takashi Sutani, Masashige Bando, Katsuhiko Shirahige   +10 more
openalex   +3 more sources

Phenotypic Overlap of Roberts and Baller-Gerold Syndromes in Two Patients With Craniosynostosis, Limb Reductions, and ESCO2 Mutations [PDF]

Frontiers in Pediatrics, 2019
Baller-Gerold (BGS, MIM#218600) and Roberts (RBS, MIM#268300) syndromes are rare autosomal recessive disorders caused, respectively, by biallelic alterations in RECQL4 (MIM*603780) and ESCO2 (MIM*609353) genes.
Elisa Adele Colombo, Hatice Mutlu-Albayrak, Yousef Shafeghati, Mine Balasar, Juliette Piard, Davide Gentilini, Davide Gentilini, Anna Maria Di Blasio, Cristina Gervasini, Lionel Van Maldergem, Lidia Larizza   +10 more
doaj   +2 more sources

The cohesin modifier ESCO2 is stable during DNA replication [PDF]

Chromosome Research, 2022
AbstractCohesion between sister chromatids by the cohesin protein complex ensures accurate chromosome segregation and enables recombinational DNA repair. Sister chromatid cohesion is promoted by acetylation of the SMC3 subunit of cohesin by the ESCO2 acetyltransferase, inhibiting cohesin release from chromatin.
Allison Jevitt, Brooke D. Rankin, Jingrong Chen, Susannah Rankin   +3 more
openalex   +3 more sources

Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.

PLoS ONE, 2020
In a process linked to DNA replication, duplicated chromosomes are entrapped in large, circular cohesin complexes and functional sister chromatid cohesion (SCC) is established by acetylation of the SMC3 cohesin subunit.
Atiq Faramarz, Jesper A Balk, Janne J M van Schie, Anneke B Oostra, Cherien A Ghandour, Martin A Rooimans, Rob M F Wolthuis, Job de Lange   +7 more
doaj   +3 more sources

The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion [PDF]

The EMBO Journal, 2018
Chromosome segregation depends on sister chromatid cohesion which is established by cohesin during DNA replication. Cohesive cohesin complexes become acetylated to prevent their precocious release by WAPL before cells have reached mitosis. To obtain insight into how DNA replication, cohesion establishment and cohesin acetylation are coordinated, we ...
Miroslav P Ivanov, René Ladurner, Ina Poser, Rebecca Beveridge, Evelyn Rampler, Otto Hudecz, Maria Novatchkova, Jean-Karim Hèriché, Gordana Wutz, Petra van der Lelij, Emanuel Kreidl, James R. A. Hutchins, Heinz Axelsson‐Ekker, Jan Ellenberg, Anthony A. Hyman, Karl Mechtler, Jan‐Michael Peters   +16 more
openalex   +5 more sources

Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2. [PDF]

PLoS Genetics, 2019
Cohesin acetyltransferases ESCO1 and ESCO2 play a vital role in establishing sister chromatid cohesion. How ESCO1 and ESCO2 are controlled in a DNA replication-coupled manner remains unclear in higher eukaryotes. Here we show a critical role of CUL4-RING
Haitao Sun, Jiaxin Zhang, Siyu Xin, Meiqian Jiang, Jingjing Zhang, Zhen Li, Qinhong Cao, Huiqiang Lou   +7 more
doaj   +3 more sources