Investigation of Structure and Function of Esco1 and Esco2 Acetyltransferases [PDF]
, 2018 Tahereh Ajam
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Humeroradial Synostosis: An Updated Classification and Differential Diagnosis Based on Genetic Aetiology. [PDF]
Clin GenetThe proposed updated classification of humeroradial synostosis is based on the molecular pathways of the genes involved: (1) chondrogenesis and osteogenesis; (2) limb development and patterning; (3) genome regulation. Thus, pathologies belonging to the same molecular type may have overlapping clinical phenotypes, helping to structure the diagnostic ...
Leduc F +5 more
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Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication. [PDF]
Adv Sci (Weinh)Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Wei P +12 more
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Molecular mechanisms underlying cortical (mal)formation: case studies of ESCO2 and EXOSC10 [PDF]
, 2021 Pauline Antonie Ulmke
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METTL16 and YTHDC1 Regulate Spermatogonial Differentiation via m6A. [PDF]
Cell ProlifThe deletion of either Mettl16 or Ythdc1 with Stra8‐Cre disrupted the gene expression related to chromosome organisation and segregation, resulting in aberrant differentiation of spermatogonia and male infertility. ABSTRACT Spermatogenesis is a highly unique and intricate process, finely regulated at multiple levels, including post‐transcriptional ...
Gu X +6 more
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Meiotic sex chromosome cohesion and autosomal synapsis are supported byEsco2 [PDF]
Life Science Alliance, 2020 In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs) and synaptonemal complexes. Here, we show that levels of ESCO2, acSMC3, and the pro-cohesion factor
François McNicoll +6 more
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Interpretable Differential Abundance Signature (iDAS). [PDF]
Small MethodsiDAS is an ANOVA‐based framework that enhances the interpretability of differential abundance signatures in single‐cell and spatial omics data. It provides a coherent and interpretable framework for grouping gene‐level associations in complex experimental designs.
Yu L, Lin Y, Xu X, Yang P, Yang JYH.
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The non-redundant function of cohesin acetyltransferase Esco2 [PDF]
Nucleus, 2012 Cohesin and cohesin regulatory proteins function in an essential pathway enabling proper cohesion and segregation of sister chromatids. Additionally, these proteins are involved in double-strand break (DSB) repair and transcriptional regulation.
Whelan, G. +3 more
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Esco2 regulates cx43 expression during skeletal regeneration in the zebrafish fin [PDF]
Developmental Dynamics, 2015 Background: Roberts syndrome (RBS) is a rare genetic disorder characterized by craniofacial abnormalities, limb malformation, and often severe mental retardation. RBS arises from mutations in ESCO2 that encodes an acetyltransferase and modifies the cohesin subunit SMC3.
Rajeswari, Banerji +3 more
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CLINICAL AND MOLECULAR RESULTS OF SIX CASES WITH ROBERTS SYNDROME: REVIEW OF CASES FROM TURKIYE
İstanbul Tıp Fakültesi Dergisi, 2022 Objective: Roberts syndrome is a rare autosomal recessive disease characterized by limb defects, prenatal onset growth retardation, and craniofacial anomalies.
Ayça Dilruba Aslanger +11 more
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