Results 61 to 70 of about 1,393 (149)

Effects of chronic hypoxia on the gene expression profile in the embryonic heart in three Chinese indigenous chicken breeds (Gallus gallus)

Frontiers in Veterinary Science, 2022
Hypoxia exposure (HE) has adverse impacts on the embryonic development of chicken, whereas the mechanism underlying the response of the heart to HE during embryo development in birds is still unclear.
Xiaofeng Li, Abdel-Moneim Eid Abdel-Moneim, Zhongze Hu, Noura M. Mesalam, Bing Yang   +4 more
doaj   +1 more source

Lactylation Genes LDHA and LDHC Alleviate Osteoarthritis by Reducing Specific B-Cell Expression: Mechanistic Exploration and Experimental Validation. [PDF]

J Cell Mol Med
ABSTRACT This study aims to elucidate the correlation between the lactylation‐related genes and the progression of knee osteoarthritis (KOA). Integrating genome‐wide association study data and expression quantitative trait locus data, Mendelian randomisation (MR) and summary‐data‐based MR analyses assessed the correlation between lactylation‐related ...
Di J, Guo Z, Di Y, Chen T, Qin Y, Xing X, Xiang C.   +6 more
europepmc   +2 more sources

Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome

Disease Models & Mechanisms, 2015
Mutations in ESCO2, one of two establishment of cohesion factors necessary for proper sister chromatid cohesion (SCC), cause a spectrum of developmental defects in the autosomal-recessive disorder Roberts syndrome (RBS), warranting in vivo analysis of ...
Stefanie M. Percival, Holly R. Thomas, Adam Amsterdam, Andrew J. Carroll, Jacqueline A. Lees, H. Joseph Yost, John M. Parant   +6 more
doaj   +1 more source

DNA damage induces Yap5-dependent transcription of ECO1/CTF7 in Saccharomyces cerevisiae.

PLoS ONE, 2020
Yeast Eco1 (ESCO2 in humans) acetyltransferase converts chromatin-bound cohesins to a DNA tethering state, thereby establishing sister chromatid cohesion.
Michael G Mfarej, Robert V Skibbens
doaj   +1 more source

Comparative Genomics Identifies Putative Interspecies Mechanisms Underlying Crbn-Sall4-Linked Thalidomide Embryopathy

Frontiers in Genetics, 2021
The identification of thalidomide–Cereblon-induced SALL4 degradation has brought new understanding for thalidomide embryopathy (TE) differences across species. Some questions, however, regarding species variability, still remain.
Thayne Woycinck Kowalski, Thayne Woycinck Kowalski, Thayne Woycinck Kowalski, Thayne Woycinck Kowalski, Thayne Woycinck Kowalski, Thayne Woycinck Kowalski, Gabriela Barreto Caldas-Garcia, Gabriela Barreto Caldas-Garcia, Julia do Amaral Gomes, Julia do Amaral Gomes, Julia do Amaral Gomes, Julia do Amaral Gomes, Lucas Rosa Fraga, Lucas Rosa Fraga, Lucas Rosa Fraga, Lucas Rosa Fraga, Lucas Rosa Fraga, Lavínia Schuler-Faccini, Lavínia Schuler-Faccini, Lavínia Schuler-Faccini, Lavínia Schuler-Faccini, Mariana Recamonde-Mendoza, Mariana Recamonde-Mendoza, Vanessa Rodrigues Paixão-Côrtes, Fernanda Sales Luiz Vianna, Fernanda Sales Luiz Vianna, Fernanda Sales Luiz Vianna, Fernanda Sales Luiz Vianna, Fernanda Sales Luiz Vianna, Fernanda Sales Luiz Vianna   +29 more
doaj   +1 more source

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer

Scientific Reports, 2021
Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity of splice factors and of ...
Simon Uzor, Sean R. Porazinski, Ling Li, Bethany Clark, Masahiko Ajiro, Kei Iida, Masatoshi Hagiwara, Abdullah A. Alqasem, Claire M. Perks, Ian D. Wilson, Sebastian Oltean, Michael R. Ladomery   +11 more
doaj   +1 more source

Forecasting New Employment Using Nonrepresentative Online Job Advertisements With an Application to the Italian and EU Labor Market

Journal of Forecasting, EarlyView.
ABSTRACT Using online job advertisement data improves the timeliness and granularity depth of analysis in the labor market in domains not covered by official data. Specifically, its variation over time may be used as an anticipator of official employment variations.
Pietro Giorgio Lovaglio, Mario Mezzanzanica   +1 more
wiley   +1 more source

Analyzing Non‐Random Selectivity in Online Job Advertisements Using Eurostat Benchmark Data and Generalized Sample Selection Models: An Application to EU Regional Labor Markets

LABOUR, EarlyView.
ABSTRACT The present paper provides an overall framework to afford the problem of non‐representativeness and non‐random selectivity arising from online job ads data, using Generalized sample selection models and Eurostat benchmark data. We jointly model the outcome intensity (number of online job ads in observed profiles, whose levels are defined by ...
Pietro Giorgio Lovaglio, Mario Mezzanzanica   +1 more
wiley   +1 more source

The Metacarpophalangeal Pattern Profile: An Old Method With New Insights Into the Evaluation of Short Stature

American Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objective To characterize the metacarpophalangeal pattern profile (MCPP) of healthy children and adolescents from São Paulo, Brazil, and to establish percentile curves by chronological age (CA), bone age (BA), and sex using the LMS method. Additionally, to compare these findings with previous population‐based data and to apply the derived ...
Marcelo Damaso Maruichi, Bruno Telma Destailleur, Giulia Maesta Apelbaum, Carlos Alberto Longui, Cristiane Kochi   +4 more
wiley   +1 more source

Expression of ethanol-induced behavioral sensitization is associated with alteration of chromatin remodeling in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: Ethanol-induced behavioral sensitization (EIBS) is proposed to play a role in early and recurring steps of addiction. EIBS does not occur uniformly in all animals even from the same inbred strain. Since recent data demonstrate that epigenetic
Béatrice Botia, Rémi Legastelois, Stéphanie Alaux-Cantin, Mickaël Naassila   +3 more
doaj   +1 more source