Results 81 to 90 of about 1,393 (149)

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, Volume 12, Issue 35, September 18, 2025.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source

iMLGAM: Integrated Machine Learning and Genetic Algorithm‐driven Multiomics analysis for pan‐cancer immunotherapy response prediction

iMeta, Volume 4, Issue 2, April 2025.
We developed an integrated Machine Learning and Genetic Algorithm‐driven Multiomics analysis (iMLGAM), an R package that combines various machine learning algorithms with genetic algorithms and multi‐omics data to predict responses to immune checkpoint blockade (ICB) therapy.
Bicheng Ye, Jun Fan, Lei Xue, Yu Zhuang, Peng Luo, Aimin Jiang, Jiaheng Xie, Qifan Li, Xiaoqing Liang, Jiaxiong Tan, Songyun Zhao, Wenhang Zhou, Chuanli Ren, Haoran Lin, Pengpeng Zhang   +14 more
wiley   +1 more source

HPV E6/E7‐Induced Acetylation of a Peptide Encoded by a Long Non‐Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer

Advanced Science, Volume 12, Issue 10, March 13, 2025.
Qi et al. report that TUBORF, a peptide encoded by lncTUBA3FP, inhibits ferroptosis to promote the malignancy of cervical cancer. HPV oncoproteins E6 and E7 upregulate TUBORF expression through CBP/p300‐mediated H3K27 acetylation of lncTUBA3FP enhancer.
Xiaoyu Qi, Jing Zhou, Xinyue Wang, Yan Shen, Yuxun Cao, Liangzi Jiang, Miaomiao Shen, Haoran Zhang, Tianjiao Wang, Pengjun Wei, Ruoqi Xu, Yue Yang, Xiangya Ding, Cong Wang, Xuemei Jia, Qin Yan, Wan Li, Chun Lu   +17 more
wiley   +1 more source

Single‐neuron analysis of aging‐associated changes in learning reveals impairments in transcriptional plasticity

Aging Cell, Volume 23, Issue 9, September 2024.
The image illustrates a single‐neuron total RNA sequencing approach designed to uncover molecular insights into age‐related learning impairments. We studied short‐term and long‐term sensitization, a type of nonassociative learning, in the sea slug Aplysia californica at three distinct ages.
Kerriann K. Badal, Abhishek Sadhu, Bindu L. Raveendra, Carrie McCracken, Sebastian Lozano‐Villada, Amol C. Shetty, Phillip Gillette, Yibo Zhao, Dustin Stommes, Lynne A. Fieber, Michael C. Schmale, Anup Mahurkar, Robert D. Hawkins, Sathyanarayanan V. Puthanveettil   +13 more
wiley   +1 more source

Mutation profiling in South African patients with Cornelia de Lange syndrome phenotype

Molecular Genetics &Genomic Medicine, Volume 12, Issue 1, January 2024.
Abstract Background Cornelia de Lange Syndrome (CdLS) presents with a variable multi‐systemic phenotype and pathogenic variants have been identified in five main genes. This condition has been understudied in African populations with little phenotypic and molecular information available.
Heather Seymour, Candice Feben, Patracia Nevondwe, Robyn Kerr, Careni Spencer, Maria Mudau, Engela Honey, Zane Lombard, Amanda Krause, Nadia Carstens   +9 more
wiley   +1 more source

Additional file 1 of ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner

, 2023
Supplementary Material ...
Hu, Juan, Yan, Jing, Chen, Yijie, Li, Xiaohui, Yang, Liu, Di, Haiyu, Zhang, Huihui, Shi, Yewen, Zhao, Junjie, Shi, Yanxia, Xu, Yinglong, Ren, Xiaoyong, Wang, Zhenghui   +12 more
openaire   +1 more source

Identification of methylation sites and signature genes with prognostic value for luminal breast cancer

BMC Cancer, 2018
Background Robust and precise molecular prognostic predictors for luminal breast cancer are required. This study aimed to identify key methylation sites in luminal breast cancer, as well as precise molecular tools for predicting prognosis.
Bin Xiao, Lidan Chen, Yongli Ke, Jianfeng Hang, Ling Cao, Rong Zhang, Weiyun Zhang, Yang Liao, Yang Gao, Jianyun Chen, Li Li, Wenbo Hao, Zhaohui Sun, Linhai Li   +13 more
doaj   +1 more source

Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families

BMC Cancer, 2019
Background In the majority of familial breast cancer (BC) families, the etiology of the disease remains unresolved. To identify missing BC heritability resulting from relatively rare variants (minor allele frequency ≤ 1%), we have performed whole exome ...
Rajendra Bahadur Shahi, Sylvia De Brakeleer, Ben Caljon, Ingrid Pauwels, Maryse Bonduelle, Sofie Joris, Christel Fontaine, Marian Vanhoeij, Sonia Van Dooren, Erik Teugels, Jacques De Grève   +10 more
doaj   +1 more source

Esco2 and cohesin regulate CRL4 ubiquitin ligase ddb1 expression and thalidomide teratogenicity

, 2022
Annie C. Sanchez, Elise D. Thren, M. Kathryn Iovine, Robert V. Skibbens   +3 more
openalex   +2 more sources

Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex [PDF]

, 2021
Pauline Antonie Ulmke, M. Sadman Sakib, Peter Ditte, Godwin Sokpor, Cemil Kerimoglu, Linh Pham, Yuanbin Xie, Xiaoyi Mao, Joachim Rosenbusch, Ulrike Teichmann, Huu Phuc Nguyen, André Fischer, Gregor Eichele, Jochen F. Staiger, Tran Tuoc   +14 more
openalex   +1 more source