Oral esketamine for patients with severe treatment-resistant depression:Effectiveness, safety, and tolerability of a six-week open-label treatment program [PDF]
Background: Oral esketamine for patients with treatment-resistant depression (TRD) could offer certain advantages over other routes, such as intravenous or intranasal, but it has not been systematically studied in a real-world setting.
Kamphuis, Jeanine +5 more
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The Association between Intranasal Esketamine and Treatment- emergent Insomnia in the Treatment of Treatment-resistant Major Depression:A Meta-analysis [PDF]
ObjectiveIntranasal (IN) esketamine represents a novel add-on treatment for treatment-resistant depression (TRD) with reported favourable effects on insomnia.
Boesjes, Rutger +6 more
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Treating Treatment-resistant Depression with Esketamine Nasal Spray When All Therapeutic Options Have Been Exhausted: Clinical Experience from a Spanish Cohort of Expanded Use [PDF]
Depressive disorder; Esketamine; Treatment-resistantTrastorno depresivo; Esketamina; Resistente al tratamientoTrastorn depressiu; Esketamina; Resistent al tractamentObjective: Treatment Resistant Depression (TRD) is commonly defined as the lack of ...
Inzoli, Benedetta +5 more
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PLoS ONEBackgroundCardio-biliary reflex can lead to cardiac arrest, brady-arrhythmia, cardiogenic shock, and other severe complications. NMDA receptor antagonists have been shown to have the effect of anti-vagal reflex. However, the regulation of vagus reflex by
Xiaodong Zhang +3 more
doaj +1 more source
Safety and tolerability of esketamine nasal spray versus quetiapine extended release in patients with treatment resistant depression [PDF]
Funding Information: This study was sponsored by Janssen EMEA. Support for third\u2011party writing assistance for this article, provided by Phoebe Kennedy, MSc, and Andrew Wilhelmsen, PhD, Costello Medical, UK, was funded by Janssen EMEA in accordance ...
Bitter, Istvan +11 more
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Towards personalized management of complex regional pain syndrome [PDF]
This dissertation illustrates how the management of CRPS should be personalized. Patients with CRPS suffer continuous pain and can experience sensory, vasomotor, sudomotor, motor and trophic symptoms in the affected extremity.
Mangnus, Tom
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Ketamine in Prevention and Treatment of Postpartum Depression - Literature Review [PDF]
Introduction and purpose: Ketamine, used as an anesthetic and analgesic, has gained considerable attention in recent years in the context of treating various psychiatric disorders, particularly the treatment of drug-resistant depression.
Chról, Michał +8 more
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Improvements in functioning and workplace productivity with esketamine nasal spray versus quetiapine extended release in patients with treatment resistant depression:Findings from a 32-week randomised, open-label, rater-blinded phase IIIb study [PDF]
Patients with treatment resistant depression (TRD) experience a greater negative impact on their functioning and productivity at home and in the workplace versus treatment-responsive patients.
Cleare, Anthony
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Esketamine in Treatment-Resistant Depression and Suicidal Ideation: A Systematic Review [PDF]
Background. Major depressive disorder affects 20% of the global population, with treatment-resistant depression in 10-30% of cases. Patients with acute suicidal ideation need immediate intervention, yet conventional antidepressants require weeks to work.
Drozd, Zuzanna +8 more
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Patient Experience with Intranasal Esketamine in Treatment-Resistant Depression: Insights from a Multicentric Italian Study (REAL-ESKperience) [PDF]
Background. Treatment-resistant depression (TRD) is a prevalent, high-burden disorder. Esketamine nasal spray (ESK-NS) has been approved for, T.R.D.; and efficacy has been observed in both clinical trials and real-world studies.
Andriola I. +28 more
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