Results 71 to 80 of about 7,663 (213)

Interventions to prevent postoperative neurocognitive complications: an umbrella review of meta‐analyses of randomised controlled trials

Anaesthesia, Volume 81, Issue 4, Page 532-540, April 2026.
Summary Introduction The certainty of the effectiveness of interventions to manage postoperative neurocognitive complications remains unclear. The objective of this umbrella review was to synthesise and evaluate the evidence for interventions aimed at reducing the incidence of peri‐operative neurocognitive complications.
Filippo D'Amico, Stefano Turi, Marco Manazza, Giuliana Lo Bianco, Giacomo Monti, Alberto Zangrillo, Giovanni Landoni, Luigi Beretta   +7 more
wiley   +1 more source

Esketamine as an opioid-sparing adjuvant for epidural labour analgesia: a randomised, double-blind trial evaluating postpartum depression

BMC Anesthesiology
Background Opioid-based epidural analgesia, while effective, is frequently associated with maternal side effects such as pruritus and potential central sensitisation.
Yi-ying Zhang, Xu-li Cheng, Li Liu, Lin Li, Yugang Diao   +4 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

results from the ICEBERG study [PDF]

Funding Information: AJO-M: received grants from Compass Pathways, Ltd., Janssen and Schuhfried GmBH; investigator driven research funded by Funda\u00E7\u00E3o para Ci\u00EAncia e Tecnologia (PTDC/SAU-NUT/3507/2021; PTDC/MED-NEU/1552/2021; PTDC/MED NEU ...
Godinov, Yordan, Mulhern-Haughey, Siobhán, Oliveira-Maia, Albino J., Rive, Benoît   +3 more
core   +1 more source

Research progress on the clinical application of esketamine

Zhongguo linchuang yanjiu
Esketamine is the S-enantiomer of racemic ketamine, which has a similar pharmacological mechanism to ketamine. Esketamine has the advantages of fast onset, fast metabolism, little impact on circulatory and respiratory functions, and strong sedative and ...
JIANG Lele, DU Xiaoxuan
doaj   +1 more source

Game Changers in the Treatment of and Engagement With Persons Living With Mental Health and Substance Use Disorders: The Role of the Nurse

International Journal of Mental Health Nursing, Volume 35, Issue 2, April 2026.
ABSTRACT The game changers in mental health and substance use disorder treatment have been shaped by historical sea changes marked by transformative advancements that have significantly enhanced patient care. Breakthroughs in psychotherapy, psychosurgery and psychopharmacology have each contributed to reshaping clinical practices, especially the ...
Arlene Kent‐Wilkinson, Sudor Ogunwemimo, Eileen Zaba   +2 more
wiley   +1 more source

Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients with Treatment-Resistant Depression: A Randomized Clinical Trial [PDF]

, 2019
Importance: Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established.
Bitter, I., Blier, P., Cubala, W. J., Daly, E. J., Divacka, I., Drevets, W. C., Duca, A. R., Fagiolini, A., Hough, D., Janik, A., Lane, R., Li, H., Li, X., Lim, P., Manji, H., Molero, P., Shelton, R. C., Singh, J. B., Thase, M. E., Trivedi, M. H., Winokur, A., Zajecka, J., Zhang, Y.   +22 more
core   +1 more source

Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study

Drug Design, Development and Therapy, 2019
Jing Wang,1,2,* Jie Huang,1,3,* Shuang Yang,1,3 Chang Cui,1,3 Ling Ye,1,3 Sai-ying Wang,4 Guo-ping Yang,1,3 Qi Pei1,2 1Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, People’s Republic
Wang J, Huang J, Yang S, Cui C, Ye L, Wang S, Yang G, Pei Q   +7 more
doaj  

Postoperative esketamine improves ventilation after video-assisted thoracoscopic lung resection: A double-blinded randomized controlled trial

Heliyon
Background: Pain management after lung resection plays a crucial role in reducing postoperative pulmonary complications (PPCs). This study aimed to examine the effect of postoperative esketamine infusion as an adjunct to opioid analgesia on ventilation ...
Mengyue Fu, Rui Xu, Guizhen Chen, Xuemei Zheng, Bin Shu, He Huang, Guangyou Duan, Yuanjing Chen   +7 more
doaj   +1 more source

Role and mechanism of esketamine in improving postoperative cognitive dysfunction in aged mice through the TLR4/MyD88/p38 MAPK pathway

Kaohsiung Journal of Medical Sciences
Postoperative cognitive dysfunction (POCD) is a significant concern for the elderly population worldwide. This study explored the effects of esketamine on aged mice with POCD and investigate its mechanism of action involving the TLR4/MyD88/MAPK pathway ...
Hu‐Jun Xu, Xian‐Peng Li, Li‐Ye Han
doaj   +1 more source