Results 61 to 70 of about 6,119 (209)

Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers

, 2017
Background Esketamine is traditionally administered via intravenous or intramuscular routes. In this study we developed a pharmacokinetic model of inhalation of nebulized esketamine with special emphasis on pulmonary absorption and ...
Marieke Niesters, Velzen, M. van, Monique van Velzen, Niesters, M., Jonkman, K., Dahan, A., Erik Olofsen, Henthorn, T., Thomas Henthorn, René Mooren, Kelly Jonkman, Duma, A., Leon Aarts, Andreas Duma, Aarts, L., Jojanneke van den Beukel, Mooren, R., Siebers, L., Liesbeth Siebers, Albert Dahan, Olofsen, E., Beukel, J. van den   +21 more
core   +1 more source

Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study

Drug Design, Development and Therapy, 2019
Jing Wang,1,2,* Jie Huang,1,3,* Shuang Yang,1,3 Chang Cui,1,3 Ling Ye,1,3 Sai-ying Wang,4 Guo-ping Yang,1,3 Qi Pei1,2 1Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, People’s Republic
Wang J, Huang J, Yang S, Cui C, Ye L, Wang S, Yang G, Pei Q   +7 more
doaj  

Differential effects of ketamine enantiomers on EEG parameters including the gamma‐delta shift phenomenon

British Journal of Pharmacology, Volume 183, Issue 12, Page 3340-3354, June 2026.
Background and Purpose Ketamine consists of two enantiomers, (R)‐ketamine and (S)‐ketamine, which exhibit distinct pharmacological properties. Currently, only the (S)‐enantiomer has been approved for the treatment of major depressive disorder, whereas recent clinical studies have failed to demonstrate an antidepressant effect for (R)‐ketamine.
Szabolcs Koncz, Dóra Pothorszki, Noémi Papp, Donát Pál, György Bagdy   +4 more
wiley   +1 more source

Effect of pretreatment with low-dose Esketamine on the Propofol requirements and the onset time of cisatracurium during the induction of general anesthesia: a prospective, randomized, double-blinded trial

BMC Anesthesiology
Background Esketamine has been increasingly used as an adjuvant for propofol-based induction. However, the effective esketamine dose for this indication remains unclear.
Rui An, Chunnan Lin, Zeguang Lu, Wenqian Lin, Hongying Tan, Tianhua Zhang, Huiting Li, Longhui Cao   +7 more
doaj   +1 more source

Prefrontal neurophysiological changes associated with subanesthetic esketamine accelerating mice emergence from propofol anesthesia

Brain Research Bulletin
Background: Recent studies have demonstrated that subanesthetic dose of ketamine or its S-enantiomer, esketamine, can paradoxically accelerate the recovery of consciousness in rodents following general anesthesia.
Yinying Sun, Bo Li, Yiting Wang, Xuliang Jiang, Su Tang, Jiayi Zhang, Jun Zhang   +6 more
doaj   +1 more source

Urothelial toxicity of esketamine in the treatment of depression

, 2020
Rationale!#!Ketamine is the first widely used substance with rapid-onset antidepressant action. However, there are uncertainties regarding its potential urothelial toxicity, particularly after repeated application.
Findeis, Hannelore, Cleare, Anthony, Sauer, Cathrin, Bauer, Michael, Ritter, Philipp   +4 more
core   +1 more source

The effect of low-dose esketamine on maternal depression after cesarean delivery

Journal of Psychosomatic Obstetrics and Gynecology
Objective To assess the impact of low-dose intravenous esketamine on postpartum depression scores in women undergoing cesarean section.Methods In a randomized, double-blind, placebo-controlled trial, 186 women aged 20–50 years receiving epidural ...
Yan Shang, Siyuan Li, Qin Zheng, Tingting Mi, Yuzhu Lv, Lichun Han, Binrong Wang   +6 more
doaj   +1 more source

Effect of esketamine on hypotension in women with preoperative anxiety undergoing elective cesarean section: a randomized, double-blind, controlled trial

Scientific Reports
To investigate the effect of low-doses esketamine on spinal anesthesia-induced hypotension in women with preoperative anxiety undergoing elective cesarean section, the randomized controlled trial enrolled 120 women aged 18–35 years who preoperative State-
Yu Qi, Meiyan Zhou, Yaqi Dong, Wenting Zheng, Qinyu Jiang, Yanyu Li, Xinghe Wang, Jia Sun, Hai Zhou, Zhengquan Hu, Liwei Wang   +10 more
doaj   +1 more source

From Trials to Clinics: Considerations for Implementing Psychedelic‐Assisted Therapy Into Clinical Practice

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Jessie Kim, Liam Lochhead, Cory R. Weissman   +2 more
wiley   +1 more source

Rapid infusion of esketamine for unipolar and bipolar depression: a retrospective chart review

, 2017
Fernanda S Correia-Melo,1 Felipe C Argolo,1 Lucas Araújo-de-Freitas,1,2 Gustavo Carneiro Leal,1 Flávio Kapczinski,3 Acioly Luiz Lacerda,4 Lucas C Quarantini1,2 1Psychiatry Service, University Hospital, Federal University of Bahia, Salvador,
Correia-Melo FS, Leal GC, Kapczinski F, Argolo FC, Araújo-de-Freitas L, Lacerda AL, Quarantini LC   +6 more
core