Results 41 to 50 of about 7,663 (213)

Are we repeating mistakes of the past? A review of the evidence for esketamine – CORRIGENDUM [PDF]

, 2021
It should be emphasised that Table 1 in the Analysis1 combines data from Phase 2 trials (including open-label and placebo-controlled trial periods) and Phase 3 trials (placebo-controlled efficacy studies, a maintenance of effect study and a long-term ...
Horowitz, Mark A, Moncrieff, Joanna
core  

Electroconvulsive therapy vs Esketamine among patients with Major Depressive Episode

European Psychiatry, 2023
Introduction Major depressive disorder is one of the most common and disabling mental disorders. More than 30% of individuals do not achieve remission after several trials of antidepressants and treatment-resistant depression (TRD) is associated with ...
M. D. R. D. R. F. D. A. Basto, O. Nombora, L. Santa Marinha, J. L. Simães, A. Horta   +4 more
doaj   +1 more source

The efficacy of nasal administration of esketamine in patients having moderate-to-severe pain after preoperative CT-guided needle localization: a randomized, double-blind, placebo-controlled trial

Frontiers in Medicine
BackgroundWhether nasal administration of esketamine can provide effective analgesia is unclear in patients with acute pain after preoperative CT-guided needle localization.MethodsIn this double-blind, randomized, placebo-controlled trial, patients were ...
Jiangning Xu, Jin Jian, Jin Jian, Yunyun Zhang, Jingxiang Wu, Jingxiang Wu, Yuwei Qiu, Yuwei Qiu   +7 more
doaj   +1 more source

Perspective: Depression in Persons with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Depression is a prevalent and disabling syndrome characterized by sustained sadness and/or anhedonia, as well as cognitive and physical symptoms. In Parkinson's disease (PD), depression is both common and clinically challenging due to overlapping symptoms and complex etiologic interactions. Major depressive disorder occurs in approximately 17%
Albert F.G. Leentjens, Gregory M. Pontone   +1 more
wiley   +1 more source

Efficacy and Safety of Dexmedetomidine‐Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Emergence delirium (ED) is a common complication in pediatric anesthesia. Although intranasal dexmedetomidine (DEX) is widely used, its application is constrained by a slow onset, residual risk of ED in some patients, and risks such as bradycardia and hypotension.
Munder Lateiresh, Alhasan Altayf, Ayham Qatza, Abubaker Alghazal, Hasan Al‐sakkaf, Muhammed Elhadi   +5 more
wiley   +1 more source

Chinese Society of Pediatric Anesthesiology Guideline for Pediatric Sedation (2025)

Pediatric Anesthesia, EarlyView.
ABSTRACT Background With the increasing variety of pediatric diagnostic procedures, a growing number of children require sedation for diagnostic examinations. Appropriate sedation protocols guarantee the safety of children during sedation and improve its efficiency.
Xingrong Song, Dongxu Lei, Yu Cui, Zhen Du, Yingping Jia, Yue Jin, Hang Tian, Ying Xu, Lifang Yang, Jianmin Zhang, Jijian Zheng, Yunxia Zuo, Liang Zhong, John Zhong, Maryrose Osazuwa, Elizabeth Drum, Charles Dean Kurth, Yue Huang, Qinghua Huang, Heqi Liu, Wei Liu, Rui Ma, Dongpi Wang, Tingting Wang, Zixin Wang, Siwei Wei, Lei Yang, Rui Zhou, Liumei Chen, Weifeng Yu, Jun Li, Mazhong Zhang, Li Zhang, Shuangquan Qu, Shoudong Pan, Rong Wei, Liming Cheng, Yaolong Chen, Xueping Li, Zhenyu Tang   +39 more
wiley   +1 more source

Respiratory depression in women receiving propofol/esketamine versus propofol/fentanyl for abortion surgery or curettage: a randomized clinical trial

Annals of Medicine
Background A combination of opioids with propofol is a popular approach to non-intubated general anaesthesia; however, this method usually results in higher incidence of respiratory depression.
Cuiwen Zhang, Jiaxin Luo, Yeqing Liao, Huiyu Cao, Xiaoshan Wu, Xiaofang Huang, Hongmeng Lan, Yuliu Lin, Huihe Chen, Xuehai Guan   +9 more
doaj   +1 more source

Median effective dose (ED50) of esketamine combined with propofol for children to inhibit response of gastroscope insertion

BMC Anesthesiology, 2023
Background Propofol is the most commonly used drug for procedural sedation during gastroscopy. However, independent use of propofol can lead to increased dosage and additional side effects.
Ming Su, Yichao Zhu, Shupeng Liu, Lijuan Song, Jiangtao Qu, Yong Zhang, Quanyi Zhang   +6 more
doaj   +1 more source

Pain management after elective caesarean section under neuraxial anaesthesia: an updated systematic review and procedure‐specific postoperative pain management (PROSPECT) recommendations

Anaesthesia, EarlyView.
Summary Introduction Elective caesarean section is a common and painful procedure. Uncontrolled pain following caesarean section can profoundly and negatively on a wide range of patient and healthcare‐centred outcomes. The aim of this systematic review was to update existing recommendations for postoperative pain management after elective caesarean ...
Gillian Crowe, Benjamin Atterton, Eva Roofthooft, Girish P. Joshi, Narinder Rawal, Christopher Wu, Axel R. Sauter, Marie‐Pierre Bonnet, Dominique Nuala Lucas, Marc Van de Velde, on behalf of the PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy, Henrik Kehlet, Stephan M. Freys, Dileep N. Lobo, Eleni Moka, Neel Desai, Dario Bugada, Patricia Lavand'Homme, Helene Beloeil, Johan Raeder, Esther M. Pogatzki‐Zahn, Eric Albrecht, Geertrui Dewinter   +22 more
wiley   +1 more source

Are we repeating mistakes of the past? A review of the evidence for esketamine [PDF]

, 2020
Esketamine has been licensed for 'treatment-resistant depression' in the USA, UK and Europe. Licensing trials did not establish efficacy: two trials were negative, one showed a statistically significant but clinically uncertain effect, and a flawed ...
Horowitz, MA, Moncrieff, J
core