Results 41 to 50 of about 5,221 (170)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, Volume 183, Issue 14, Page 3897-3919, July 2026.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Role and mechanism of esketamine in improving postoperative cognitive dysfunction in aged mice through the TLR4/MyD88/p38 MAPK pathway

Kaohsiung Journal of Medical Sciences
Postoperative cognitive dysfunction (POCD) is a significant concern for the elderly population worldwide. This study explored the effects of esketamine on aged mice with POCD and investigate its mechanism of action involving the TLR4/MyD88/MAPK pathway ...
Hu‐Jun Xu, Xian‐Peng Li, Li‐Ye Han
doaj   +1 more source

Research progress on the clinical application of esketamine

Zhongguo linchuang yanjiu
Esketamine is the S-enantiomer of racemic ketamine, which has a similar pharmacological mechanism to ketamine. Esketamine has the advantages of fast onset, fast metabolism, little impact on circulatory and respiratory functions, and strong sedative and ...
JIANG Lele, DU Xiaoxuan
doaj   +1 more source

A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes

The Journal of Physiology, Volume 604, Issue 13, Page 5561-5584, 1 July 2026.
Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner, Fabio Frangiamore, Frédéric Sonak, Josef Madl, Thomas Seidel, Peter Kohl, Eva A. Rog‐Zielinska   +6 more
wiley   +1 more source

Postoperative esketamine improves ventilation after video-assisted thoracoscopic lung resection: A double-blinded randomized controlled trial

Heliyon
Background: Pain management after lung resection plays a crucial role in reducing postoperative pulmonary complications (PPCs). This study aimed to examine the effect of postoperative esketamine infusion as an adjunct to opioid analgesia on ventilation ...
Mengyue Fu, Rui Xu, Guizhen Chen, Xuemei Zheng, Bin Shu, He Huang, Guangyou Duan, Yuanjing Chen   +7 more
doaj   +1 more source

Ketamine Dosing Across Clinical Indications: A Narrative Review Organized by Proposed NMDA‐Related Mechanisms

The Journal of Clinical Pharmacology, Volume 66, Issue 6, June 2026.
Abstract Ketamine is a non‐competitive antagonist at the N‐methyl‐D‐aspartate (NMDA) glutamate receptor. It was approved by the US Food and Drug Administration for anesthesia in 1970. The only other related US regulatory approval since then has been for esketamine nasal spray for depression in 2019. Over this time ketamine has been repurposed by mainly
Paul Glue, Ben Beaglehole
wiley   +1 more source

Esketamine as an opioid-sparing adjuvant for epidural labour analgesia: a randomised, double-blind trial evaluating postpartum depression

BMC Anesthesiology
Background Opioid-based epidural analgesia, while effective, is frequently associated with maternal side effects such as pruritus and potential central sensitisation.
Yi-ying Zhang, Xu-li Cheng, Li Liu, Lin Li, Yugang Diao   +4 more
doaj   +1 more source

Perspective: Depression in Persons with Parkinson's Disease

Movement Disorders, Volume 41, Issue 6, Page 1355-1361, June 2026.
Abstract Depression is a prevalent and disabling syndrome characterized by sustained sadness and/or anhedonia, as well as cognitive and physical symptoms. In Parkinson's disease (PD), depression is both common and clinically challenging due to overlapping symptoms and complex etiologic interactions. Major depressive disorder occurs in approximately 17%
Albert F.G. Leentjens, Gregory M. Pontone   +1 more
wiley   +1 more source

Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study

Drug Design, Development and Therapy, 2019
Jing Wang,1,2,* Jie Huang,1,3,* Shuang Yang,1,3 Chang Cui,1,3 Ling Ye,1,3 Sai-ying Wang,4 Guo-ping Yang,1,3 Qi Pei1,2 1Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, People’s Republic
Wang J, Huang J, Yang S, Cui C, Ye L, Wang S, Yang G, Pei Q   +7 more
doaj  

Effect of pretreatment with low-dose Esketamine on the Propofol requirements and the onset time of cisatracurium during the induction of general anesthesia: a prospective, randomized, double-blinded trial

BMC Anesthesiology
Background Esketamine has been increasingly used as an adjuvant for propofol-based induction. However, the effective esketamine dose for this indication remains unclear.
Rui An, Chunnan Lin, Zeguang Lu, Wenqian Lin, Hongying Tan, Tianhua Zhang, Huiting Li, Longhui Cao   +7 more
doaj   +1 more source