Results 21 to 30 of about 7,663 (213)

Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs [PDF]

, 2020
Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Croubels, Siska, Devreese, Mathias, Dockx, Robrecht, Duchateau, Luc, Peremans, Kathelijne, Polis, Ingeborgh, Vlerick, Lise   +6 more
core   +1 more source

The Ketamine Side Effect Tool (KSET):A comprehensive measurement-based safety tool for ketamine treatment in psychiatry [PDF]

, 2022
Objectives: On a background of the rapidly expanding clinical use of ketamine and esketamine for treatment of depression and other conditions, we examined safety monitoring, seeking to identify knowledge gaps relevant to clinical practice.
Bayes, Adam, Brunoni, Andre, Fam, Johnson, Galvez, Veronica, Glue, Paul, Loo, Colleen K., Martin, Donel, McLoughlin, Declan M., McShane, Rupert, Murrough, James W., Parikh, Sagar, Park, Lawrence, Riva-Posse, Patricio, Schoevers, Robert, Short, Brooke, Tor, Phern Chern, Veraart, Jolien, Zarate, Carlos A.   +17 more
core   +3 more sources

Esketamine Anesthetizes Mice With a Similar Potency to Racemic Ketamine

Dose-Response, 2023
Esketamine, the right-handed optical isomer of racemic ketamine, has recently become widely used for anesthesia and analgesia as a replacement for racemic ketamine.
Xiaofan Ma, Jiali Peng, Yelin Chen, Zeyi Wang, Qiang Zhou, Jia Yan, Hong Jiang   +6 more
doaj   +1 more source

The median effective concentration of propofol in combination with different doses of esketamine during gastrointestinal endoscopy in adults

Frontiers in Pharmacology, 2022
We designed a four-arm randomized controlled trial to investigate the median effective concentration (EC50) of propofol in combination with different doses of esketamine inducing appropriate depth of anaesthesia during gastrointestinal endoscopy in ...
Miaomiao Feng, Miaomiao Feng, Gaoxiang Shi, Gaoxiang Shi, Wenjing Cui, Wenjing Cui, Ning Zhang, Ning Zhang, Qipeng Xie, Qipeng Xie, Weiwei Zhang, Weiwei Zhang   +11 more
doaj   +1 more source

ED90 of epidural esketamine with 0.075% ropivacaine for labor analgesia in nulliparous parturients: a prospective, randomized and dose-finding study

Frontiers in Pharmacology, 2023
Background: Because it has been reported that racemic ketamine had a local anesthetic-sparing effect when used for epidural analgesia this would suggest the likelihood of a potential advantage (less pruritus) over opioid drugs.
Siwen Lou, Qiang Du, Liwei Yu, Qingfu Wang, Jing Yu, Zhong Mei   +5 more
doaj   +1 more source

Esketamine improves propofol-induced brain injury and cognitive impairment in rats

Translational Neuroscience, 2022
As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of
Xu Guiping, Wang Yang, Chen Zhe, Zhang Yuxuan, Zhang Xuexue, Zhang Guichao   +5 more
doaj   +1 more source

Improvement of functional neurological disorder after administration of esketamine nasal spray: a case report [PDF]

, 2021
Esketamina; Trastorn neurològic funcional; Paràlisi mixtaEsketamina; Trastorno neurológico funcional; Parálisis mixtaEsketamine; Functional neurological disorder; Mixed paralysisFunctional neurological disorder (FND) is a complex neuropsychiatric ...
Arteaga Henriquez, Gara, Ramos Quiroga, José Antonio, Rodríguez Urrutia, Amanda, Soto Angona, Oscar, Vendrell Serres, Júlia   +4 more
core   +1 more source

Personalised Interventions - A Precision Approach for the Next Generation of Dietary Intervention Studies [PDF]

, 2017
Acknowledgments The research of Baukje de Roos is supported by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS). Lorraine Brennan acknowledges The European Research Council ERC (647783).
Brennan, Lorraine, de Roos, Baukje
core   +2 more sources

Safety of esketamine nasal spray: Analysis of post-marketing reports submitted to the FDA adverse event reporting system in the first year on the market

European Psychiatry, 2021
Introduction The approval of the esketamine nasal spray for treatment-resistant depression in March 2019 by the Food and Drug Administration (FDA), and few months later by the European Medicine Agency, triggered a vivid debate and many concerns, mainly
C. Gastaldon, E. Raschi, J. Kane, C. Barbui   +3 more
doaj   +1 more source

Ketamine: NMDA receptors and beyond [PDF]

, 2016
Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +2 more sources