Results 21 to 30 of about 5,221 (170)

Potential ‘anti-cancer’ effects of esketamine on proliferation, apoptosis, migration and invasion in esophageal squamous carcinoma cells

European Journal of Medical Research, 2023
Background Esketamine, an N-methyl-D-aspartate receptor antagonist, is commonly used for anesthesia and analgesia clinically. It was reported to negatively regulate cell proliferation, metastasis and apoptosis in cancer cells, including lung cancer and ...
Chao Li, Jingpu Shi, Sisi Wei, Huiqun Jia   +3 more
doaj   +1 more source

The efficacy of nasal administration of esketamine in patients having moderate-to-severe pain after preoperative CT-guided needle localization: a randomized, double-blind, placebo-controlled trial

Frontiers in Medicine
BackgroundWhether nasal administration of esketamine can provide effective analgesia is unclear in patients with acute pain after preoperative CT-guided needle localization.MethodsIn this double-blind, randomized, placebo-controlled trial, patients were ...
Jiangning Xu, Jin Jian, Jin Jian, Yunyun Zhang, Jingxiang Wu, Jingxiang Wu, Yuwei Qiu, Yuwei Qiu   +7 more
doaj   +1 more source

Efficacy and safety comparison of esketamine-propofol with nalbuphine-propofol for upper gastrointestinal endoscopy in children: a multi-center randomized controlled trial

Frontiers in Pediatrics, 2023
Background and AimsAnesthetics such as propofol, esketamine and nalbuphine are used during the upper gastrointestinal endoscopy to achieve and maintain the desired sedation level.
Xiaosu Zheng, Jinjin Huang, Sisi Wei, Yingying Tao, Yang Shen, Yanting Wang, Pan He, Mazhong Zhang, Ying Sun   +8 more
doaj   +1 more source

Patients With Atypical Symptoms of Depression Respond Better to Lithium Augmentation Than Patients Without Atypical Symptoms

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Understanding the differences in treatment response between subtypes of major depressive disorder (MDD) may help to prevent lengthy trial‐and‐error processes by identifying effective treatment options. The aim of the study was to investigate the impact of atypical features of MDD (MDD‐A) on the response to lithium augmentation (LA)
Hannah Buchbauer, Mazda Adli, Peter Schlattmann, Maximilian Berger, Tom Bschor, Thomas Stamm, Joachim Behr, Roland Ricken, Pichit Buspavanich   +8 more
wiley   +1 more source

Critically Ill Children Show Disrupted Sleep Patterns and Atypical Electroencephalograms: An Observational Cohort Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Sleep disruptions are common in hospitalised children. This study described sleep in critically ill and non‐critically ill hospitalised children, including young infants and patients with central nervous system injuries. Methods This observational cohort study included two groups: critically ill children admitted to a paediatric intensive ...
Eris van Twist, Arnout B. G. Cramer, Sascha C. A. T. Verbruggen, Maartje Louter, Karlien Veldscholte, Koen F. M. Joosten, Matthijs de Hoog, Karla Biesheuvel, Dirk C. G. Straver, Rogier C. J. de Jonge   +9 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Median effective dose (ED50) of esketamine combined with propofol for children to inhibit response of gastroscope insertion

BMC Anesthesiology, 2023
Background Propofol is the most commonly used drug for procedural sedation during gastroscopy. However, independent use of propofol can lead to increased dosage and additional side effects.
Ming Su, Yichao Zhu, Shupeng Liu, Lijuan Song, Jiangtao Qu, Yong Zhang, Quanyi Zhang   +6 more
doaj   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

British Journal of Pharmacology, EarlyView.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga, Robert Kronstrand, Bianca Schranz, Nick van Zijl, Sebastian Karlman, Soma Aref, Tobias Rautio, Svante Vikingsson, Mattias Persson, Henrik Green   +9 more
wiley   +1 more source

Sub-anesthetic dose of esketamine decreases postoperative opioid self-administration after spine surgery: a retrospective cohort analysis

Scientific Reports
The use of intraoperative sub-anesthetic esketamine for postoperative analgesia is controversial. In this study, the impact of sub-anesthetic esketamine on postoperative opioid self-administration was determined.
Hongyu Zheng, Peng Zhang, Shengnan Shi, Xue Zhang, Qiang Cai, Xingrui Gong   +5 more
doaj   +1 more source

Respiratory depression in women receiving propofol/esketamine versus propofol/fentanyl for abortion surgery or curettage: a randomized clinical trial

Annals of Medicine
Background A combination of opioids with propofol is a popular approach to non-intubated general anaesthesia; however, this method usually results in higher incidence of respiratory depression.
Cuiwen Zhang, Jiaxin Luo, Yeqing Liao, Huiyu Cao, Xiaoshan Wu, Xiaofang Huang, Hongmeng Lan, Yuliu Lin, Huihe Chen, Xuehai Guan   +9 more
doaj   +1 more source