Results 1 to 10 of about 7,076 (205)

Plasma esketamine and noresketamine levels and antidepressant response with oral esketamine treatment [PDF]

European Journal of Pharmacology
Oral esketamine has relatively low and variable bioavailability, which may complicate broader use as an antidepressant. This study aimed to investigate associations between different pharmacokinetic outcomes and change in depressive symptoms following oral esketamine administration in patients with treatment-resistant depression.
Daniel Touw, Sanne Smith-Apeldoorn, Robert Schoevers   +2 more
exaly   +5 more sources

Intermittent versus continuous esketamine infusions for long-term pain modulation in complex regional pain syndrome: protocol of a randomized controlled non-inferiority study (KetCRPS-2)

BMC Musculoskeletal Disorders, 2023
Background Complex regional pain syndrome (CRPS) is a chronic pain condition of an extremity. While achieving pain relief in CRPS is challenging, esketamine infusions can accomplish pain relief for several weeks post-infusion in a subgroup of CRPS ...
Thomas J. P. Mangnus, Maaike Dirckx, Krishna D. Bharwani, Sara J. Baart, Theodora A. M. Siepman, Ken Redekop, Willem A. Dik, Cecile C. de Vos, Frank J. P. M. Huygen   +8 more
doaj   +1 more source

Midazolam Attenuates Esketamine-Induced Overactive Behaviors in Mice Before the Sedation, but Not During the Recovery

Frontiers in Veterinary Science, 2022
Esketamine showed more potency, more rapid recovery from anesthesia, and less psychotomimetic side effects when compared with ketamine. However, the patients still experience psychotomimetic side effects of esketamine.
Qinjun Chu, Meng Mao, Yafan Bai, Liwei Sun, Dongqing Zhang, Ping Zheng, Xiaogao Jin, Xiaogao Jin, Xiaogao Jin, Xiaogao Jin   +9 more
doaj   +1 more source

Efficacy and safety of esketamine for sedation among patients undergoing gastrointestinal endoscopy: a systematic review and meta-analysis

BMC Anesthesiology, 2023
Background Patients who undergo gastrointestinal endoscopy often require propofol-based sedation combined with analgesics. At present, the efficacy and safety of esketamine as an adjunct to propofol for sedation during endoscopic procedures in patients ...
Xianghong Lian, Yunzhu Lin, Ting Luo, Yang Jing, Hongbo Yuan, Yixin Guo   +5 more
doaj   +1 more source

Subanaesthetic dose of esketamine during induction delays anaesthesia recovery a randomized, double-blind clinical trial

BMC Anesthesiology, 2022
Background Esketamine is an antagonist of the N-methyl-D-aspartate receptor (NMDA receptor) that is widely used for multimodal analgesia. In addition to analgesia, sedation is another important effect of esketamine.
Cao Zhang, Jiangqin He, Qinye Shi, Fangping Bao, Jianhong Xu   +4 more
doaj   +1 more source

Exploring the role of esketamine in alleviating depressive symptoms in mice via the PGC-1α/irisin/ERK1/2 signaling pathway

Scientific Reports, 2023
Esketamine provides an immediate and noticeable antidepressant effect, although the underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been implicated in the alleviation of depressive symptoms, whether irisin ...
Na Hu, Xuemei Chen, Chengchuan Chen, Xing Liu, Peng Yi, Tianhao Xu, Jing Jia, Jianguo Feng, Chunxiang Zhang, Xiaobin Wang   +9 more
doaj   +1 more source

Esketamine Anesthetizes Mice With a Similar Potency to Racemic Ketamine

Dose-Response, 2023
Esketamine, the right-handed optical isomer of racemic ketamine, has recently become widely used for anesthesia and analgesia as a replacement for racemic ketamine.
Xiaofan Ma, Jiali Peng, Yelin Chen, Zeyi Wang, Qiang Zhou, Jia Yan, Hong Jiang   +6 more
doaj   +1 more source

ED90 of epidural esketamine with 0.075% ropivacaine for labor analgesia in nulliparous parturients: a prospective, randomized and dose-finding study

Frontiers in Pharmacology, 2023
Background: Because it has been reported that racemic ketamine had a local anesthetic-sparing effect when used for epidural analgesia this would suggest the likelihood of a potential advantage (less pruritus) over opioid drugs.
Siwen Lou, Qiang Du, Liwei Yu, Qingfu Wang, Jing Yu, Zhong Mei   +5 more
doaj   +1 more source

Esketamin [PDF]

pharma-kritik, 2021
In Form eines Nasensprays (Spravato®) ist das S-Enantiomer von Ketamin zur Behandlung einer «therapieresistenten» Depression zugelassen. Hinsichtlich der psychischen Auswirkungen teilt diese Form die Eigenschaften von Ketamin.
openaire   +1 more source

Esketamine improves propofol-induced brain injury and cognitive impairment in rats

Translational Neuroscience, 2022
As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of
Xu Guiping, Wang Yang, Chen Zhe, Zhang Yuxuan, Zhang Xuexue, Zhang Guichao   +5 more
doaj   +1 more source