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Case report: two cases of rhabdomyolysis following esketamine treatment [PDF]
Frontiers in PsychiatryMajor depressive disorder is a mental disorder affecting millions of people worldwide. A considerable proportion of patients demonstrate a lack of response to conventional treatment.
René Zeiss +3 more
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Overcoming the myths of esketamine administration: different and not difficult [PDF]
Frontiers in Psychiatry, 2023 Intranasal esketamine for treatment-resistant depression has been introduced and approved by the FDA and EMA in 2019 and 2020, respectively. Since then, the administration practices were found different among countries. Major depression has a high impact
Florian Buchmayer, Siegfried Kasper
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Plasma esketamine and noresketamine levels and antidepressant response with oral esketamine treatment [PDF]
European Journal of PharmacologyOral esketamine has relatively low and variable bioavailability, which may complicate broader use as an antidepressant. This study aimed to investigate associations between different pharmacokinetic outcomes and change in depressive symptoms following oral esketamine administration in patients with treatment-resistant depression.
Jolien K.E. Veraart +4 more
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Research progress on the clinical application of esketamine
Zhongguo linchuang yanjiuEsketamine is the S-enantiomer of racemic ketamine, which has a similar pharmacological mechanism to ketamine. Esketamine has the advantages of fast onset, fast metabolism, little impact on circulatory and respiratory functions, and strong sedative and ...
JIANG Lele, DU Xiaoxuan
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Esketamine use in real-world clinical practice in patients with treatment-resistant depression
European PsychiatryBackground Esketamine has been shown to produce a major antidepressant response in patients with treatment-resistant depression (TRD). We evaluated the factors associated with achieving remission in these individuals.
Ismael Conejero +9 more
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HeliyonBackground: Pain management after lung resection plays a crucial role in reducing postoperative pulmonary complications (PPCs). This study aimed to examine the effect of postoperative esketamine infusion as an adjunct to opioid analgesia on ventilation ...
Mengyue Fu +7 more
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Drug Design, Development and TherapyXu Zeng,1,2 Xianjie Zhang,2 Wencai Jiang,2,* Xinyu Zhou1,* 1Department of Anaesthesiology, Chengdu Medical College, Chengdu, People’s Republic of China; 2Department of Anesthesiology, People’s Hospital of Deyang City, Deyang, People’s Republic of
Zeng X, Zhang X, Jiang W, Zhou X
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Esketamine Anesthetizes Mice With a Similar Potency to Racemic Ketamine
Dose-Response, 2023 Esketamine, the right-handed optical isomer of racemic ketamine, has recently become widely used for anesthesia and analgesia as a replacement for racemic ketamine.
Xiaofan Ma +6 more
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Frontiers in Pharmacology, 2023 Background: Because it has been reported that racemic ketamine had a local anesthetic-sparing effect when used for epidural analgesia this would suggest the likelihood of a potential advantage (less pruritus) over opioid drugs.
Siwen Lou +5 more
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Frontiers in Pharmacology, 2022 We designed a four-arm randomized controlled trial to investigate the median effective concentration (EC50) of propofol in combination with different doses of esketamine inducing appropriate depth of anaesthesia during gastrointestinal endoscopy in ...
Miaomiao Feng +11 more
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