Results 51 to 60 of about 6,119 (209)

Perspective: Depression in Persons with Parkinson's Disease

Movement Disorders, Volume 41, Issue 6, Page 1355-1361, June 2026.
Abstract Depression is a prevalent and disabling syndrome characterized by sustained sadness and/or anhedonia, as well as cognitive and physical symptoms. In Parkinson's disease (PD), depression is both common and clinically challenging due to overlapping symptoms and complex etiologic interactions. Major depressive disorder occurs in approximately 17%
Albert F.G. Leentjens, Gregory M. Pontone   +1 more
wiley   +1 more source

Pharmacological Management, Safety, and Outcomes in Bipolar Disorder: An Integrated Narrative Review of Clinical and Translational Evidence

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
This graph summarizes bipolar disorder management, showing pharmacological treatments including lithium, valproate, antipsychotics, combination therapy, and emerging agents. It links these treatments to outcomes such as relapse reduction, mortality benefits, and cognitive effects, while highlighting safety issues, poor adherence, pregnancy risks, and ...
Gudisa Bereda
wiley   +1 more source

Effects of the Different Doses of Esketamine on Postoperative Quality of Recovery in Patients Undergoing Modified Radical Mastectomy: A Randomized, Double-Blind, Controlled Trial

, 2022
Min Zhu, Siqi Xu, Xia Ju, Shengbin Wang, Xitong Yu Department of Anesthesiology, The Anqing Medical Center of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Anqing, People’s Republic of ChinaCorrespondence: Xia ...
Ju X, Zhu M, Wang S, Xu S, Yu X
core  

Efficacy and Safety of Dexmedetomidine‐Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Pediatric Anesthesia, Volume 36, Issue 6, Page 617-627, June 2026.
ABSTRACT Background Emergence delirium (ED) is a common complication in pediatric anesthesia. Although intranasal dexmedetomidine (DEX) is widely used, its application is constrained by a slow onset, residual risk of ED in some patients, and risks such as bradycardia and hypotension.
Munder Lateiresh, Alhasan Altayf, Ayham Qatza, Abubaker Alghazal, Hasan Al‐sakkaf, Muhammed Elhadi   +5 more
wiley   +1 more source

Anesthesia and Postoperative Pain Management in Hip Reconstructions in Children With Neurodevelopmental Conditions: A Proposal for a Peri‐ and Postoperative Pain Management Protocol

Paediatric and Neonatal Pain, Volume 8, Issue 2, June 2026.
ABSTRACT Progressive hip displacement is a common problem in children with neurodevelopmental conditions, often leading to painful dislocation and impaired function. Hip reconstruction may be necessary to maintain containment but these reconstructions are major surgery in this vulnerable population.
Renée A. van Stralen, Susanne D. Verbaas, Jaap Johannes Tolk, Maaike Dirckx, Frank Weber, Thomas G. de Leeuw   +5 more
wiley   +1 more source

Role and mechanism of esketamine in improving postoperative cognitive dysfunction in aged mice through the TLR4/MyD88/p38 MAPK pathway

Kaohsiung Journal of Medical Sciences
Postoperative cognitive dysfunction (POCD) is a significant concern for the elderly population worldwide. This study explored the effects of esketamine on aged mice with POCD and investigate its mechanism of action involving the TLR4/MyD88/MAPK pathway ...
Hu‐Jun Xu, Xian‐Peng Li, Li‐Ye Han
doaj   +1 more source

Acute‐Phase Interventions After Self‐Harm for Preventing Suicide and Recurrence: A Systematic Review and Meta‐Analysis

Acta Psychiatrica Scandinavica, Volume 153, Issue 6, Page 610-626, June 2026.
ABSTRACT Introduction Suicide risk is markedly elevated following presentation after self‐harm, yet the evidence base for interventions initiated in the immediate post‐presentation period has not been synthesized with specific attention to this high‐risk window. Clarifying which early interventions may reduce adverse outcomes is essential for informing
Guilherme Pimenta Roncete, Luis C. Farhat, Loren Beiram, Bianca Besteti Fernandes Damiano, Craig J. Bryan, Karina L. Ramirez, Euripedes Constantino Miguel, Rodolfo Furlan Damiano   +7 more
wiley   +1 more source

Esketamine as an opioid-sparing adjuvant for epidural labour analgesia: a randomised, double-blind trial evaluating postpartum depression

BMC Anesthesiology
Background Opioid-based epidural analgesia, while effective, is frequently associated with maternal side effects such as pruritus and potential central sensitisation.
Yi-ying Zhang, Xu-li Cheng, Li Liu, Lin Li, Yugang Diao   +4 more
doaj   +1 more source

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, Volume 121, Issue 6, Page 1616-1621, June 2026.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Pain management after elective caesarean section under neuraxial anaesthesia: an updated systematic review and procedure‐specific postoperative pain management (PROSPECT) recommendations

Anaesthesia, Volume 81, Issue 6, Page 819-839, June 2026.
Summary Introduction Elective caesarean section is a common and painful procedure. Uncontrolled pain following caesarean section can profoundly and negatively on a wide range of patient and healthcare‐centred outcomes. The aim of this systematic review was to update existing recommendations for postoperative pain management after elective caesarean ...
Gillian Crowe, Benjamin Atterton, Eva Roofthooft, Girish P. Joshi, Narinder Rawal, Christopher Wu, Axel R. Sauter, Marie‐Pierre Bonnet, Dominique Nuala Lucas, Marc Van de Velde, on behalf of the PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy, Henrik Kehlet, Stephan M. Freys, Dileep N. Lobo, Eleni Moka, Neel Desai, Dario Bugada, Patricia Lavand'Homme, Helene Beloeil, Johan Raeder, Esther M. Pogatzki‐Zahn, Eric Albrecht, Geertrui Dewinter   +22 more
wiley   +1 more source