Results 91 to 100 of about 15,738 (196)

A survey of Top 200 Drugs—Inconsistent Practice of Drug Strength Expression for Drugs Containing Salt Forms [PDF]

, 2012
Many ionizable drugs are developed and marketed as salt forms. However, there are no clear US regulatory guidelines on drug strength labeling for salts. The strengths of some drugs are expressed as salts and some as free acids/bases.
Prohotsky, Daniel, Zhao, Fang
core   +2 more sources

The therapeutic effect of high-dose esomeprazole on stress ulcer bleeding in trauma patients

Chinese Journal of Traumatology, 2015
Purpose: To compare the therapeutic effects of different doses of intravenous esomeprazole on treating trauma patients with stress ulcer bleeding. Methods: A total of 102 trauma patients with stress ulcer bleeding were randomly divided into 2 groups: 52
Cui Lihong, Li Chao, Wang Xiaohui, Yan Zhihui, He Xing, Gong Sandong   +5 more
doaj  

Minimal access surgery compared with medical management for gastro-oesophageal reflux disease : five year follow-up of a randomised controlled trial (REFLUX) [PDF]

, 2013
Peer reviewedPublisher ...
Boachie, C, Campbell, M K, Cotton, S C, Grant, A M, Heading, R C, Krukowski, Z H, Ramsay, C R, REFLUX Trial Group   +7 more
core   +1 more source

Proton pump inhibitor-induced Sweet’s syndrome: report of acute febrile neutrophilic dermatosis in a woman with recurrent breast cancer

Dermatology Practical & Conceptual, 2015
Background: Sweet’s syndrome, also referred to as acute febrile neutrophilic dermatosis, can either occur as an idiopathic disorder or associated with another condition, including cancer, or induced by exposure to a drug.
Philip R. Cohen
doaj   +1 more source

Assessing CYP2C19 Ontogeny in Neonates and Infants Using Physiologically Based Pharmacokinetic Models: Impact of Enzyme Maturation Versus Inhibition

CPT: Pharmacometrics & Systems Pharmacology, 2019
The objective of this study was to develop pediatric physiologically based pharmacokinetic (PBPK) models for pantoprazole and esomeprazole. Pediatric PBPK models were developed by Simcyp version 15 by incorporating cytochrome P450 (CYP)2C19 maturation ...
Peng Duan, Fang Wu, Jason N. Moore, Jeffrey Fisher, Victor Crentsil, Daniel Gonzalez, Lei Zhang, Gilbert J. Burckart, Jian Wang   +8 more
doaj   +1 more source

Proton Pump Inhibitors Therapy in Children with Gastroesophageal Reflux [PDF]

, 2013
Proton pump inhibitors (PPI) has been widely used by clinicians to treat diseases that require suppression of gastric acid. PPI work by inhibiting the proton pump in gastric parietal cells.In adult patients, PPI hasbeen widely studied and showed ...
Hegar, B. (Badriul), Reynaldo, A. (Aldo)
core  

Efficacy and safety of tegoprazan (LXI-15028) vs. esomeprazole in patients with erosive esophagitis: A multicenter, randomized, double-blind, non-inferiority phase Ⅲ trial

Chinese Medical Journal
. Background:. An evidence gap still exists regarding the efficacy and safety of tegoprazan in patients with erosive esophagitis (EE) in China. This study aimed to verify the efficacy and safety of tegoprazan vs.
Huiyun Zhu, Qian Xue, Yingxiao Song, Zhenyu Zhang, Xing Li, Shengxiang Lyu, Qiang Zhan, Fei Liu, Lungen Lu, Liang Zhong, Weixing Chen, Dong Shao, Yanbing Ding, Deliang Liu, Xiaozhong Yang, Zhiming Huang, Zhaoshen Li, Yiqi Du, Yuanyuan Ji   +18 more
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Pharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions

Drug Design, Development and Therapy, 2022
Hae Won Lee,1,2 Woo Youl Kang,1,2 Wookjae Jung,1,2 Mi-Ri Gwon,1,2 Kyunghee Cho,3 Young-Ran Yoon,1,2 Sook Jin Seong1,2 1Department of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea; 2Department of ...
Lee HW, Kang WY, Jung W, Gwon MR, Cho K, Yoon YR, Seong SJ   +6 more
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Addition of bedtime lafutidine inhibits nocturnal acid-breakthrough and improves sleep quality in gastroesophageal reflux disease patients on esomeprazole: a randomized controlled trial

Scientific Reports
This study aims to evaluate the acid inhibition and clinical improvement of the addition of bedtime lafutidine to esomeprazole in comparison with esomeprazole only in Gastroesophageal reflux disease (GERD) patients with nocturnal symptoms. We conducted a
Dongke Wang, Ruohang He, Xiaohao Zhang, Chaofan Duan, Tao Bai, Junying Xu, Xuelian Xiang, Xiaohua Hou   +7 more
doaj   +1 more source

Relationship between esomeprazole dose and timing to heartburn resolution in selected patients with gastroesophageal reflux disease

Clinical and Experimental Gastroenterology, 2010
Roy C Orlando1, Sherry Liu2, Marta Illueca31Department of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA, 2Department of Statistics and Informatics, 3Department of Clinical Development, AstraZeneca LP, Wilmington, DE,
Roy C Orlando, Sherry Liu, Marta Illueca
doaj