Results 21 to 30 of about 210,346 (221)

Clinicopathological significance of c-MYC in esophageal squamous cell carcinoma

Tumor Biology, 2017
Esophageal squamous cell carcinoma is one of the most common malignant tumors. The oncogene c-MYC is thought to be important in the initiation, promotion, and therapy resistance of cancer.
Yu Lian, Xiangdong Niu, Hui Cai, Xiaojun Yang, Haizhong Ma, Shixun Ma, Yupeng Zhang, Yifeng Chen   +7 more
doaj   +1 more source

The expression of protease-activated receptors in esophageal carcinoma cells: the relationship between changes in gene expression and cell proliferation, apoptosis in vitro and growing ability in vivo

Cancer Cell International, 2018
Background Protease-activated receptors (PARs) are a family of four G protein-coupled receptors expressed widely in many types of cells. PAR1, 2, and 4 have been shown to play an important role in many of the physiological activities of cells and many ...
Ping Jiang, Shu De Li, Zhi Gang Li, Yue Chun Zhu, Xiao Jia Yi, Si Man Li   +5 more
doaj   +1 more source

Downregulation of Ubiquitin Inhibits the Aggressive Phenotypes of Esophageal Squamous Cell Carcinoma

Technology in Cancer Research & Treatment, 2020
Purpose: Esophageal cancer is one of the most common malignancies worldwide. Ubiquitin-dependent degradation of regulatory proteins reportedly plays a central role in diverse cellular processes.
Yi Gao MD, Wei Mo MD, Li Zhong MD, Huimin Jia MD, Yiren Xu BA, Ji Zhang BA, Xiaohui Xu MD, Weidong Shen PhD, Fangjun Wang PhD, Tengfei Li MD, Pengfei Liu PhD, Shuyu Zhang PhD   +11 more
doaj   +1 more source

Giant esophageal liposarcoma with squamous cell carcinoma resected via the cervical approach: a case report

Surgical Case Reports, 2022
Background Liposarcoma is one of the most common soft tissue sarcomas, but is extremely rarely found in the esophagus. There have been no reports of esophageal liposarcoma together with superficial carcinoma of the esophagus.
Tomohiro Okura, Yasuhiro Shirakawa, Yuki Katsura, Takuya Yano, Michihiro Ishida, Daisuke Satoh, Yasuhiro Choda, Masanori Yoshimitsu, Nakano Kanyu, Hiroyoshi Matsukawa, Hitoshi Idani, Masazumi Okajima, Shigehiro Shiozaki   +12 more
doaj   +1 more source

Impact of Radiotherapy, Chemotherapy and Surgery in Multimodal Treatment of Locally Advanced Esophageal Cancer [PDF]

, 2011
Objectives: It was the aim of this study to assess our institutional experience with definitive chemoradiation (CRT) versus induction chemotherapy followed by CRT with or without surgery (C-CRT/S) in esophageal cancer.
Adams R, Annina Lemminger, Bedenne L, Berger B, Bernhard Berger, Claus Belka, Cooper JS, Delcambre C, Denham JW, Herskovic A, Katharina Stahlberg, Malthaner RA, Martin Bleif, Michael Bamberg, Minsky BD, Mizumoto M, Rades D, Sarraf M, Seung SK, Shi XH, Stahl M, Tepper J, Wolf M, Zhang Z   +23 more
core   +1 more source

Case Report: A rare successful case of treating cerebral air embolism following the removal of a central venous catheter without intracardiac structural abnormalities

Frontiers in Surgery
BackgroundCerebral air embolism following the removal of a central venous catheter is a rare and often fatal complication, resulting in severe neurological deficits and potentially death.Case presentationWe report a unique case involving a 57-year-old ...
Mingzhe Song, Mingzhe Song, Wenxiang Wang, Wenxiang Wang, Jie Wu, Jie Wu   +5 more
doaj   +1 more source

Global Incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries [PDF]

, 2018
Oesophageal cancers (adenocarcinomas [AC] and squamous cell carcinomas [SCC]) are characterized by high incidence/mortality in many countries. We aimed to delineate its global incidence and mortality, and studied whether socioeconomic development and its
Chan, Francis K.L., Chiu, Philip W.Y., Fung, Franklin D.H., Hamilton, Willie, Jiang, Johnny Y., Ng, Enders K.W., Qiao, Youlin, Sung, Joseph J.Y., Wang, Harry H.X., Whiteman, David C., Wong, Martin C.S., Wu, Justin C.Y., Yu, Jun   +12 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Programmed cell death 6 interacting protein (PDCD6IP) and Rabenosyn-5 (ZFYVE20) are potential urinary biomarkers for upper gastrointestinal cancer [PDF]

, 2015
PURPOSE: Cancer of the upper digestive tract (uGI) is a major contributor to cancer-related death worldwide. Due to a rise in occurrence, together with poor survival rates and a lack of diagnostic or prognostic clinical assays, there is a clear need ...
Adachi, Ballehaninna, Banks, Baron, Brennan, Caffrey, Chang, Chechlinska, Chung, Clemons, den Broek, Driemel, Ferlay, Fry, Gonzales, Gronn, Gungor, Guo, Hamm, Haren, Havanapan, Hennies, Honda, Hu, Hua, Husi, Jacobs, Jayapalan, Kentsis, Kim, Koomen, Lee, Lee, Lee, Lee, Li, Lyubimova, Makawita, Maliniemi, Matsumoto, McKiernan, Melle, Muley, Navaroli, Nicol, Pan, Passerini, Rastogi, Ren, Sanchez-Carbayo, Shah, Shahbaz Sarwar, Singh, Sofiadis, Song, Tanzer, Taylor, Toriola, Van, Villanueva, Wang, Wang, Wei, Winden, Xie, Zelvyte, Zhang, Zhang, Zhang   +68 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source