Results 41 to 50 of about 785,637 (307)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Recurrent laryngeal nerve lymph nodes status prediction after neoadjuvant therapy for thoracic esophageal squamous cell carcinoma

Insights into Imaging
Objectives Accurately predicting recurrent laryngeal nerve lymph nodes (RLNs) status after neoadjuvant therapy is challenging but essential for efficient dissection of RLNs and for lowering local recurrence rates in patients with esophageal cancer ...
Fengze Wu, Chao Luo, Shumin Zhou, Zexue Peng, Guangying Ruan, Xin Yang, Shuqi Li, Wenjie Huang, Lizhi Liu, Jian Zhou, Baodan Liang, Haojiang Li   +11 more
doaj   +1 more source

Compressive Sonoelastography Findings of Esophageal Carcinoma

, 2019
Objective: The aim of this study was to evaluate the compressive sonoelastography findings of primary esophageal ...
Afak Durur-Karakaya, Adem Karaman, Balta, Hilal, Mahmut Subasi, Durur-Karakaya, Afak, KARAMAN, Adem, Subasi, Mahmut, Hilal Balta   +7 more
core   +1 more source

Systemic Therapy for Esophageal Squamous Cell Carcinoma

, 2020
With more understanding of the tumor biology, esophageal squamous cell carcinoma (ESCC) and adenocarcinoma are increasingly recognized as different disease entities and are managed with different treatment approaches.
Lam, KO, So, TH, Chan, WLW, Kwong, DLW
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

MicroRNA-148a-3p suppresses cell proliferation and migration of esophageal carcinoma by targeting CEP55

Cellular & Molecular Biology Letters, 2021
This study evaluated microRNA-148a-3p in esophageal carcinoma cells. The prediction of bioinformatics analysis revealed that microRNA-148a-3p may target CEP55.
Yong Lin, Yushan Chen, Rongqiang Shen, Dingzhu Chen, Yimin Lin   +4 more
doaj   +1 more source

[Esophageal carcinoma].

Annali dell'Istituto superiore di sanita, 1996
After early rises, oesophageal cancer mortality rates have tended to level off in Italy over the last two decades, and are now intermediate on a European scale (4.7/100000 males, 0.8/100000 females, world standard). This reflects the trends in consumption of the major risk factors for the disease, tobacco and alcohol, particularly in men. Within Italy,
C. La Vecchia, A. Decarli
openaire   +2 more sources

Whole-Slide Imaging of Esophageal Squamous Cell Carcinoma

, 2020
Whole-slide imaging (WSI) contributes to medical education, collaboration, quality assurance, examination, and consultation in pathology. The images obtained from WSI are of high quality and could be stored indefinitely.
Lam, AK, Melissa Leung, Leung, M, Alfred K. Lam   +3 more
core   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source