Results 51 to 60 of about 129,621 (342)

Breast radiation-associated secondary malignancies: A review

Clinical Surgical Oncology, 2023
Secondary malignancies are a late complication of radiation treatment for primary cancer through DNA damage. Specifically after breast cancer radiation, a number of tissues are vulnerable to radiation damage and have increased risk for developing ...
Sarah Poland, Wataru Ebina, Franco Muggia, Amber Guth   +3 more
doaj   +1 more source

Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis [PDF]

, 2006
Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several investigations support the view that common fragile sites play a role in carcinogenesis.
A Caputo, A Matsuyama, A Musio, Alda Maria Puliti, AM Casper, Angela Re, CD Hou, CT Miller, D Corà, D Corà, D Iliopoulos, Davide Cora, E Birney, H Ishii, I Sbrana, I Sbrana, Isabella Sbrana, ISCN, J Bartkova, J Hoshen, K Mimori, KA Cimprich, KA Nyberg, LV O'Keefe, M Ashburner, M Fabbri, M Schwartz, Michele Caselle, Newman MEJ, NS Chang, P Hoglund, RS Cha, S Corbin, S Gasser, SL Reiner, T Oyama, TW Glover, U Krummrei, VG Gorgoulis, Y Zhu   +39 more
core   +5 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Therapeutic approaches to gastroesophageal junction adenocarcinomas [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108681/1/nyas12532 ...
Agrawal, Aloia, Apisarnthanarax, Ayyappan, Baardwijk, Bang, Barbour, Bettstetter, Blom, Bogush, Bogush, Bruzzi, Brücher, Brücher, Brücher, Brücher, Cerfolio, Chang, Chirieac, Cunningham, Dikken, Dulak, Eto, Farris, Gonzalez, Griffin, Gurland, Hagen, Heijl, Heijl, Illig, Kwee, Lambrecht, Langer, Langer, Loon, Mandard, Mann, Marsman, Medical Research Council Oesophageal Cancer Working Group, Miller, Moertel, Peyre, Peyre, Ronellenfitsch, Rossum, Sarkaria, Schneider, Shapiro, Siewert, Sjoquist, Smit, Stahl, Swisher, Swisher, Takebayashi, Tepper, Therasse, Walsh, Westerterp, Xie   +60 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Esophageal pulmonary fistula – a rare complication of radiation therapy: a case report

Journal of Medical Case Reports, 2018
Background Esophageal respiratory fistulae are abnormal communications between the esophagus and the respiratory system. They are either congenital or acquired.
Laetitia Buemi, Salvatore Stefanelli, Philippe Bichard, Mickaël Luscher, Minerva Becker   +4 more
doaj   +1 more source

RFLMDA: A Novel Reinforcement Learning-Based Computational Model for Human MicroRNA-Disease Association Prediction

Biomolecules, 2021
Numerous studies have confirmed that microRNAs play a crucial role in the research of complex human diseases. Identifying the relationship between miRNAs and diseases is important for improving the treatment of complex diseases.
Linqian Cui, You Lu, Jiacheng Sun, Qiming Fu, Xiao Xu, Hongjie Wu, Jianping Chen   +6 more
doaj   +1 more source

Comparative proteomic analysis of esophageal squamous cell carcinoma [PDF]

, 2005
Ranking as the fourth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of the leading causes of cancer death in China. One of the main reasons for the low survival rate is that neoplasms in esophagus are not detected until they ...
Chiu, JF, He, QY, Kwong, DLW, Qi, Y, Wang, L   +4 more
core   +1 more source