Results 121 to 130 of about 446,222 (404)

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

Journal of Lipid Research, 2002
Lysophosphatidic acid is a multifunctional phospholipid mediator and elicits a variety of biological responses in vitro and in vivo. Evidence is accumulating that lysophosphatidic acid plays important physiological roles in diverse mammalian tissues and ...
Takayuki Sugiura, Shinji Nakane, Seishi Kishimoto, Keizo Waku, Yasuko Yoshioka, Akira Tokumura   +5 more
doaj   +1 more source

Optimizing Management of Patients With Barrett’s Esophagus and Low-Grade or No Dysplasia Based on Comparative Modeling [PDF]

, 2019
Amir‐Houshang Omidvari, Ayman Ali, William D. Hazelton, Sonja Kroep, Minyi Lee, Steffie K. Naber, Brianna N. Lauren, Sassan Ostvar, Ellen Richmond, Chung Yin Kong, Joel H. Rubenstein, Iris Lansdorp‐Vogelaar, E. Georg Luebeck, Chin Hur, John M. Inadomi   +14 more
openalex   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Peroral endoscopic myotomy for Jackhammer esophagus: to cut or not to cut the lower esophageal sphincter

Endoscopy International Open, 2016
Background and study aims: With the success of peroral endoscopic myotomy (POEM) in treatment of achalasia, its successful application to other spastic esophageal motility disorders such as Jackhammer esophagus has been noted. The question of whether the
R. Bechara, H. Ikeda, H. Inoue
semanticscholar   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

p53 protein in esophageal mucosa of individuals at high risk of squamous cell carcinoma of the esophagus [PDF]

, 2001
Renato Borges Fagundes, Caroline Mello, Patricia Tollens, Antônio Carlos Kruel Pütten, Mário Bernardes Wagner, L.F.E. Moreira, Sérgio Gabriel Silva de Barros   +6 more
openalex   +1 more source

Multiscale Construction, Evaluation, and Application of Organoids

Advanced Science, EarlyView.
Organoids are pivotal models with transformative biomedical potential. A comprehensive multi‐scale perspective is presented, encompassing dual‐scale construction, four‐dimensional evaluation, triple‐point application, and an analysis of the current challenges faced by organoid technology, aiming to advance organoid research and its biomedical ...
Wanting Ma, Zhenglin Dong, Zhu'anzhen Zheng, Long Bai, Xingcai Zhang, Jiacan Su   +5 more
wiley   +1 more source

Successful closure of chronic, nonhealing tubercular esophagobronchial fistula with an over‑the‑scope clip

Journal of Digestive Endoscopy, 2017
Esophagobronchial fistula is an uncommon complication of esophageal or mediastinal tuberculosis. A 35‑year‑old man, a known case of esophageal tuberculosis, who had received 9 months of antitubercular therapy (ATT) presented with persistent cough. He had
Surinder Singh Rana, Harshal Mandavdhare, Vishal Sharma, Ravi Sharma, Lovneet Dhalaria, Anmol Bhatia, Rajesh Gupta, Usha Dutta   +7 more
doaj   +1 more source

Exclusive right thoracic approach for esophagus surgery [PDF]

, 2017
Chuan Li, Nan Ge, Yi Shen, Wenjie Jiao
openalex   +1 more source

Rethinking Matrigel: The Complex Journey to Matrix Alternatives in Organoid Culture

Advanced Science, EarlyView.
Matrigel remains the most widely used scaffold in organoid and 3D culture despite its murine origin, variability, and translational limitations. This review discusses the barriers to replacing Matrigel with xeno‐free alternatives and introduces practical tools, including a matrix selection checklist and scaffold assessment criteria, to guide the ...
Lisa Wolff, Sven Hendrix
wiley   +1 more source