Results 51 to 60 of about 340,355 (361)

Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma

BMC Cancer, 2018
Background Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown.
Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao, Weimin Mao   +10 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Surgical technique of da Vinci robotic-assisted minimally invasive esophagectomy(RAMIE) expert experiences

Intelligent Surgery
Esophageal cancer is a prevalent disease in thoracic surgery, and surgery is currently the main treatment method. It can completely remove the tumor and improve the patient's quality of life.
Chengyuan Fang, Luquan Zhang, Hao Liang, Yanzhong Xin, Wei Zheng, Jianqun Ma   +5 more
doaj   +1 more source

Identifying DNA Methylation Biomarkers for Non-Endoscopic Detection of Barrett’s Esophagus

Science Translational Medicine, 2018
Combining DNA methylation markers with a swallowable device for sampling the distal esophagus effectively detects Barrett’s neoplasias. A test that goes down easy Barrett’s esophagus is a premalignant condition of the distal esophagus that increases the ...
H. Moinova, T. LaFramboise, J. Lutterbaugh, A. Chandar, J. Dumot, A. Faulx, W. Brock, Omar De la Cruz Cabrera, K. Guda, J. Barnholtz-Sloan, P. Iyer, M. Canto, Jean S. Wang, N. Shaheen, P. Thota, J. Willis, A. Chak, S. Markowitz   +17 more
semanticscholar   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Evolution of DNA ploidy during squamous cell carcinogenesis in the esophagus.

, 2001
Image and flow cytometry was used to study the nuclear DNA content (ploidy) during the squamous cell carcinogenesis in the esophagus. The present retrospective study comprised 26 surgical specimens of squamous cell carcinomas (SCC) in patients who ...
Ballini, J.P., Caron, C.T., Fontolliet, C., Blant, S.A., Monnier, P., Laurini, N.R.   +5 more
core   +2 more sources

Risk factors and prediction models for severe radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing chemoradiotherapy

Discover Oncology
Objective This study aimed to investigate the factors associated with severe radiation-induced oral mucositis (SRIOM) in nasopharyngeal carcinoma (NPC) patients undergoing chemoradiotherapy (CRT) and to establish a prediction model for SRIOM.
Yi Liang, XiaoQin Wang, XunRen Shi, XinXiong Fei   +3 more
doaj   +1 more source

Is It Barrett's Esophagus or Gastric Heterotopia

Case Reports in Gastroenterology, 2014
Columnar epithelium in the distal part of the esophagus is generally related to Barrett's esophagus. Barrett's esophagus is a well-known premalignant lesion for adenocarcinoma of the esophagus.
Zeynel Mungan
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa [PDF]

, 2002
Background: Minichromosome maintenance (Mcm) proteins are essential for eukaryotic DNA replication, and their expression implies potential for cell proliferation.
Going, J.J., Keith, W.N., Stuart, RC, Stuart, R.C., Stoeber, K, Neilson, L, Stoeber, K., Williams, G.H., Williams, GH, Going, JJ, Keith, WN, Neilson, L.   +11 more
core   +1 more source