Results 41 to 50 of about 241,618 (304)

Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma

BMC Cancer, 2018
Background Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown.
Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao, Weimin Mao   +10 more
doaj   +1 more source

Surgical technique of da Vinci robotic-assisted minimally invasive esophagectomy(RAMIE) expert experiences

Intelligent Surgery
Esophageal cancer is a prevalent disease in thoracic surgery, and surgery is currently the main treatment method. It can completely remove the tumor and improve the patient's quality of life.
Chengyuan Fang, Luquan Zhang, Hao Liang, Yanzhong Xin, Wei Zheng, Jianqun Ma   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Risk factors and prediction models for severe radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing chemoradiotherapy

Discover Oncology
Objective This study aimed to investigate the factors associated with severe radiation-induced oral mucositis (SRIOM) in nasopharyngeal carcinoma (NPC) patients undergoing chemoradiotherapy (CRT) and to establish a prediction model for SRIOM.
Yi Liang, XiaoQin Wang, XunRen Shi, XinXiong Fei   +3 more
doaj   +1 more source

Is It Barrett's Esophagus or Gastric Heterotopia

Case Reports in Gastroenterology, 2014
Columnar epithelium in the distal part of the esophagus is generally related to Barrett's esophagus. Barrett's esophagus is a well-known premalignant lesion for adenocarcinoma of the esophagus.
Zeynel Mungan
doaj   +1 more source

Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

, 2013
AIM: To assess tumour regression grade (TRG) and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS: Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal ...
Kelly, Jamie, Iveson, T., Underwood, T.J., Rees, Charlotte, Bailey, Ian, Bateman, Andrew R., Byrne, James, Sharland, Donna, Noble, Fergus, Bateman, Adrian C., Nolan, Luke   +10 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Identification of potential drug targets and possible drugs for esophageal carcinoma from genetic insights: a comprehensive two-sample Mendelian randomization study

Discover Oncology
Background Esophageal carcinoma (EC) is the eighth most common cancer, which is a major health problem on a global scale. Comprehensive treatments such as surgery, radiotherapy and chemotherapy have demonstrated efficacy in certain patients with early ...
Juan Wang, Ji Sun, Chen Liang, Haibin Ou, Jiong Liu, Aoqing Ye, Qiuji Wu, Yu Liu   +7 more
doaj   +1 more source

Time Trends of Endoscopic and Pathological Diagnoses Related to Gastroesophageal Reflux Disease in a Chinese Population: Eight Years Single Institution Experience

, 2011
P>The discrepancy between Eastern and Western countries exists regarding the time trends of Barrett's esophagus (BE) /adenocarcinoma. We aimed to elucidate this issue through a retrospective review of the endoscopic and pathological diagnoses of ...
CHEN, MEI-JYH;LEE, YI-CHIA;CHIU, HAN-MO;WU, MING-SHIANG;WANG, HSIU-PO;LIN, JAW-TOWN, 陳美志;李宜家;邱瀚模;吳明賢;王秀伯;林肇堂   +1 more
core   +1 more source