Results 91 to 100 of about 855,886 (285)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The essential norm of a composition operator mapping into Qk type spaces
Journal of Function Spaces and Applications, 2008 An asymptotic formula for the essential norm of the composition operator Cφ(f):=f∘φ, induced by an analytic self-map φ of the unit disc, mapping from the α-Bloch space ℬα or the Dirichlet type space Dαp into Qk(p,q) is established in terms of an integral
Marko Kotilainen, Jouni Rättyä
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Is Meat the New Tobacco? Regulating Food Demand in the Age of Climate Change [PDF]
, 2019 Switching from a meat-heavy to a plant-based diet is one of the highest-impact lifestyle changes for climate mitigation and adaptation. Conventional demand-side energy policy has focused on increasing consumption of efficient machines and fuels ...
Chenyang, Lingxi
core
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Essential norm of substitution operators on L p spaces
Indian Journal of Pure and Applied Mathematics, 2012 Let \((X,\Sigma, \mu)\) be a \(\sigma\)-finite measure space. Suppose that \(\varphi:X \to X\) is a non-singular transformation, that is, \(\mu\circ \varphi^{-1} \ll \mu\), and let \(u\) be a \(\Sigma\)-measurable function on \(X\). By the Radon-Nikodým theorem, for every \(f\in L^1\) there exists a \(\mu\)-unique function \(\tilde{f}_{\varphi}^{u}\in ...
Jabbarzadeh, M. R., Estaremi, Y.
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Journal of Function Spaces, 2018 We compute upper and lower bounds for essential norm of difference of composition operators acting from weighted Bergman spaces to Bloch-type spaces.
Ram Krishan +2 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source