A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase. [PDF]
Mol Biol Cell, 2015 Eco1p acetylates the cohesin subunit Smc3p to establish cohesion. It was believed that Smc3p-K113 acetylation promoted cohesion by antagonizing Wpl1p.
Guacci V +5 more
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A multi-step pathway for the establishment of sister chromatid cohesion. [PDF]
PLoS Genetics, 2007 The cohesion of sister chromatids is mediated by cohesin, a protein complex containing members of the structural maintenance of chromosome (Smc) family. How cohesins tether sister chromatids is not yet understood.
Mark Milutinovich +4 more
doaj +3 more sources
Biology, 2021 Cohesion between replicated chromosomes is essential for chromatin dynamics and equal segregation of duplicated genetic material. In the G1 phase, the ring-shaped cohesin complex is loaded onto duplex DNA, enriching at replication start sites, or ...
Sarah S. Henrikus, Alessandro Costa
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LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. [PDF]
PLoS Biology, 2012 Successful execution of the meiotic program depends on the timely establishment and removal of sister chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific cohesin REC-8 at metaphase ...
Yonatan B Tzur +7 more
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AtCTF7 is required for establishment of sister chromatid cohesion and association of cohesin with chromatin during meiosis in Arabidopsis. [PDF]
BMC Plant Biol, 2013 BackgroundThe establishment of sister chromatid cohesion followed by its controlled release at the metaphase to anaphase transition is necessary for faithful segregation of chromosomes in mitosis and meiosis. Cohesion is established by the action of Ctf7/
Singh DK +3 more
europepmc +3 more sources
Sister chromatid cohesion establishment during DNA replication termination. [PDF]
Science, 2022 The cohesin complex tethers sister chromatids together from the moment they are generated in S-phase until their separation in anaphase1,2. This fundamental phenomenon, called sister chromatid cohesion, underpins orderly chromosome segregation.
Cameron G +8 more
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Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome [PDF]
Disease Models & Mechanisms, 2015 Mutations in ESCO2, one of two establishment of cohesion factors necessary for proper sister chromatid cohesion (SCC), cause a spectrum of developmental defects in the autosomal-recessive disorder Roberts syndrome (RBS), warranting in vivo analysis of ...
Stefanie M. Percival +6 more
doaj +5 more sources
Cell Stress, 2023 Chromatin assembly and the establishment of sister chromatid cohesion are intimately connected to the progression of DNA replication forks. Here we examined the genetic interaction between the heterotrimeric chromatin assembly factor-1 (CAF-1), a central
Nagham Ghaddar +3 more
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Replication factor C complexes play unique pro- and anti-establishment roles in sister chromatid cohesion. [PDF]
PLoS ONE, 2010 Recent studies have lead to a rapid expansion of sister chromatid cohesion pathways. Of particular interest is the growth in classifications of anti-establishment factors-now including those that are cohesin-associated (Rad61/WAPL and Pds5) or DNA ...
Marie E Maradeo, Robert V Skibbens
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Establishment of sister chromatid cohesion. [PDF]
Curr Biol, 2009 Skibbens RV.
europepmc +2 more sources