Results 91 to 100 of about 6,803 (208)

Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis

BioEssays, Volume 48, Issue 1, January 2026.
The synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Ariel L. Gold, Yumi Kim
wiley   +1 more source

Suppression of allelic recombination and aneuploidy by cohesin is independent of Chk1 in Saccharomyces cerevisiae.

PLoS ONE, 2014
Sister chromatid cohesion (SCC), which is established during DNA replication, ensures genome stability. Establishment of SCC is inhibited in G2. However, this inhibition is relived and SCC is established as a response to DNA damage, a process known as ...
Shay Covo, Eric Chiou, Dmitry A Gordenin, Michael A Resnick   +3 more
doaj   +1 more source

Mechanistic Investigation of Nitidine Chloride‐Mediated Anti‐Colorectal Cancer Activity: Centromere‐Associated Protein E Targeting via Integrated Molecular Dynamics, Spatial Transcriptomic and Single‐Cell Approaches

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
Colorectal cancer (CRC) has high incidence and mortality, with conventional chemotherapy having severe side effects and drug resistance; traditional Chinese medicine‐derived nitidine chloride (NC) has anti‐tumour activity but unknown anti‐CRC mechanisms, whereas centromere‐associated protein E (CENPE), aberrantly expressed in malignancies, is a ...
Bin Li, Zhi‐Su Liu, Ke‐Jun Wu, Zong‐Yu Li, Wei Zhang, Hui Li, Rong‐Quan He, Di‐Yuan Qin, Jing‐Wen Ling, Jin‐Cheng Li, Gang Chen   +10 more
wiley   +1 more source

DNA damage induces Yap5-dependent transcription of ECO1/CTF7 in Saccharomyces cerevisiae.

PLoS ONE, 2020
Yeast Eco1 (ESCO2 in humans) acetyltransferase converts chromatin-bound cohesins to a DNA tethering state, thereby establishing sister chromatid cohesion.
Michael G Mfarej, Robert V Skibbens
doaj   +1 more source

Replisome progression complex links DNA replication to sister chromatid cohesion in Xenopus egg extracts [PDF]

This is the author's version of a work that was accepted for publication in Genes to Cells. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be ...
タナカ, ヒロシ, 田中, 博志
core   +1 more source

Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening [PDF]

, 2016
Cohesin stably holds together the sister chromatids from S phase until mitosis. To do so, cohesin must be protected against its cellular antagonist Wapl. Eco1 acetylates cohesin's Smc3 subunit, which locks together the sister DNAs. We used yeast genetics
Celie, P.H. (Patrick H.), Chapard, C. (Christophe), Elbatsh, A.M.O. (Ahmed M.O.), Fish, A. (Alexander), Haarhuis, J.H.I. (Judith H.I.), Medema, R.H. (Rene), Nasmyth, K. (Kim), Petela, N. (Naomi), Ristic, D. (Dejan), Rowland, B.D. (Benjamin D.), Stadnik, M. (Magda), Wyman, C. (Claire)   +11 more
core   +2 more sources

An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic

Journal of Animal Breeding and Genetics, Volume 143, Issue 1, Page 35-49, January 2026.
ABSTRACT Meiotic recombination is an essential process for shuffling genetic diversity in sexually reproducing organisms, can vary within and between individuals in response to intrinsic and extrinsic factors, and can be heritable. Interestingly, recombination rate has been found to vary with age in some species, but to date, there have been no ...
Evelyn Jade, Mathew D. Littlejohn, Katie Eketone, Richard J. Spelman, Jessica Stapley, Anna W. Santure   +5 more
wiley   +1 more source

Maintenance of genome integrity via activities of the cohesin network [PDF]

, 2014
Correct segregation of sister chromatids is an important mechanism for keeping the genome intact. The cohesin complex holds the sister chromatids together from the time of their formation during replication, until separation at ...
Lindgren, Emma
core   +1 more source

Diploid origins and early genome stabilization in the allotetraploid Arabidopsis suecica

New Phytologist, Volume 249, Issue 1, Page 524-538, January 2026.
Summary Polyploidization, followed by genome downsizing, is a recurrent evolutionary cycle that dramatically reshapes genome structure. Newly formed polyploids must quickly adjust their cell division machinery to maintain stable chromosome inheritance, while long‐term stabilization involves rediploidization, returning the genome to a diploid‐like state.
Robin Burns, Anna Glushkevich, Aboli Kulkarni, Uliana K. Kolesnikova, Filip Kolář, Alison Dawn Scott, Polina Yu. Novikova   +6 more
wiley   +1 more source

Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.

PLoS ONE, 2020
In a process linked to DNA replication, duplicated chromosomes are entrapped in large, circular cohesin complexes and functional sister chromatid cohesion (SCC) is established by acetylation of the SMC3 cohesin subunit.
Atiq Faramarz, Jesper A Balk, Janne J M van Schie, Anneke B Oostra, Cherien A Ghandour, Martin A Rooimans, Rob M F Wolthuis, Job de Lange   +7 more
doaj   +1 more source