Results 101 to 110 of about 6,803 (208)
The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects. [PDF]
, 2018 Genome instability is associated with tumorigenesis. Here, we identify a role for the histone Htz1, which is deposited by the Swr1 chromatin-remodeling complex (SWR-C), in preventing genome instability in the absence of the replication fork/replication ...
Branzei, Dana +5 more
core +2 more sources
The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability
Cytoskeleton, Volume 82, Issue 12, Page 804-814, December 2025.ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou +6 more
wiley +1 more source
Cohesin and chromosome segregation [PDF]
, 2018 Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is established between ...
Makrantoni, Vasso, Marston, Adele L
core +1 more source
Health Science Reports, Volume 8, Issue 12, December 2025.ABSTRACT Background and Aims Chromosomal nondisjunction is the primary etiology of Down syndrome; however, genetic variations, environmental causes, and maternal etiologies also contribute to a great extent. The objective of this review is to evaluate these multifaceted factors during pregnancy.
Md. Sohel Rana +2 more
wiley +1 more source
Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions
MedComm, Volume 6, Issue 12, December 2025.A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu +4 more
wiley +1 more source
A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1 [PDF]
, 2015 Defects during chromosome replication in eukaryotes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at stalled DNA replication forks.
Bentley +9 more
core +4 more sources
The FEBS Journal, Volume 292, Issue 23, Page 6163-6181, December 2025.Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan +5 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.ABSTRACT This study aims to elucidate the correlation between the lactylation‐related genes and the progression of knee osteoarthritis (KOA). Integrating genome‐wide association study data and expression quantitative trait locus data, Mendelian randomisation (MR) and summary‐data‐based MR analyses assessed the correlation between lactylation‐related ...
Jingkai Di +6 more
wiley +1 more source
The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]
, 2015 Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
core +1 more source