Results 111 to 120 of about 6,803 (208)

A SUMO-dependent step during establishment of Sister Chromatid Cohesion

, 2013
Los anillos de cohesina, formados por las proteínas Smc1, SMC3, Scc1 y Scc3, se unen topológicamente al DNA, manteniendo las parejas de cromátidas hermanas unidas desde la duplicación del DNA hasta el comienzo de la anafase. Esta función, conocida como Cohesión entre Cromátidas Hermanas, permite la biorientación de los cromosomas en el huso mitótico y,
openaire   +2 more sources

K29‐Linked Ubiquitination of Transcription Regulators Controls Cell Proliferation in the Unfolded Protein Response

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Under endoplasmic reticulum stress, cells activate the unfolded protein response (UPR). During the UPR, the cohesin complex at the promoter of cell proliferation‐related genes undergoes K29‐linked ubiquitination, recruiting the cohesin release factor WAPL to release cohesin, leading to transcriptional downregulation and inhibition of cell growth ...
Qiushuang Zhang, Xucong Teng, Yicong Dai, Yuncong Wu, Hongwei Hou, Jinghong Li   +5 more
wiley   +1 more source

Functional characterization of the Saccharomyces cerevisiae protein Chl1 reveals the role of sister chromatid cohesion in the maintenance of spindle length during S-phase arrest

BMC Genetics, 2011
Background Metaphase cells have short spindles for efficient bi-orientation of chromosomes. The cohesin proteins hold sister chromatids together, creating Sister Chromatid Cohesion (SCC) that helps in the maintenance of short spindle lengths in metaphase.
Sanyal Kaustuv, Hajra Sujata, Laha Suparna, Das Shankar P, Sinha Pratima   +4 more
doaj   +1 more source

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand

The Journal of Pathology, Volume 267, Issue 3, Page 261-274, November 2025.
Abstract Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini.
Raksawan Deenonpoe, Molly A Guscott, Sasithorn Watcharadetwittaya, Isabel L McNeill, Daniela Moralli, Nadeem Shaikh, Sarah E McClelland   +6 more
wiley   +1 more source

Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts [PDF]

, 2005
Sister chromatid cohesion is essential for proper segregation of the genome in mitosis and meiosis. Central to this process is cohesin, a multi-protein complex conserved from yeast to human.
Hirano, T., Losada, A., Yokochi, T.
core   +1 more source

Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.

The Journal of biological chemistry, 2003
A growing body of evidence suggests that establishment of sister chromatid cohesion is dependent on replication fork passage over a precohesion area. In Saccharomyces cerevisiae, this process involves an alternative replication factor C (RFC) complex that contains the four small RFC subunits as well as CTF18, CTF8, and DCC1.
Carolin J, Merkle, Larry M, Karnitz, John T, Henry-Sánchez, Junjie, Chen   +3 more
openaire   +2 more sources

Sister chromatid cohesion establishment occurs in concert with lagging strand synthesis [PDF]

Cohesion establishment is central to sister chromatid tethering reactions and requires Ctf7/Eco1-dependent acetylation of the cohesin subunit Smc3. Ctf7/Eco1 is essential during S phase, and a number of replication proteins (RFC complexes, PCNA and the ...
Brosh RM, Gary R, Gerring SL, Reagan MS, Robert V. Skibbens, Soumya Rudra   +5 more
core   +2 more sources

The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts. [PDF]

, 2003
Chromosome condensation is required for the physical resolution and segregation of sister chromatids during cell division, but the precise role of higher order chromatin structure in mitotic chromosome functions is unclear.
Deehan, Renee, Heald, Rebecca, Maresca, Thomas J, Wignall, Sarah M   +3 more
core   +4 more sources

Displacement and re-accumulation of centromeric cohesin during transient pre-anaphase centromere splitting [PDF]

, 2007
The ring-shaped cohesin complex links sister chromatids until their timely segregation during mitosis. Cohesin is enriched at centromeres where it provides the cohesive counterforce to bipolar tension produced by the mitotic spindle.
A Lengronne, A Lengronne, A Losada, A Losada, A Salic, A Tóth, BE McGuinness, C Michaelis, C Sjögren, CA Eckert, CG Pearson, CH Haering, D Ivanov, EF Glynn, F Uhlmann, F Uhlmann, F Uhlmann, Frank Uhlmann, G Goshima, G Goshima, G-L Moldovan, H Dewar, IC Waizenegger, K Nabeshima, K Nasmyth, K Nasmyth, Katsuhiko Shirahige, L Ström, M Knop, Maria T. Ocampo-Hafalla, N Nonaka, NCD Hornig, P Bernard, PC Megee, R Ciosk, RD Shelby, RV Skibbens, RV Skibbens, S Hughes-Schrader, SA Weber, T Higuchi, T Hirano, T Tanaka, T Tanaka, TS Kitajima, TU Tanaka, WD Warren, X He, Y Blat, Y Katou, Yuki Katou   +50 more
core   +2 more sources

Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions [PDF]

, 2012
During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together.
Amon, Angelika B., Brar, Gloria A., Miller, Matthew P., Unal, Elcin   +3 more
core   +3 more sources