Results 121 to 130 of about 6,803 (208)

Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction [PDF]

, 2018
SummaryWhen human cells enter mitosis, chromosomes undergo substantial changes in their organisation to resolve sister chromatids and compact chromosomes.
Eykelenboom, John K, Fukagawa, Tatsuo, Gierlinski, Marek, Hegarat, Nadia, Hochegger, Helfrid, Pollard, Hilary, Tanaka, Tomoyuki U, Yue, Zuojun   +7 more
core   +2 more sources

The role of Chl1 DNA helicase in cohesion deposition and establishment [PDF]

Sister chromatid cohesion is crucial for the accurate transmission of genetic material during cell division. The conserved family of cohesin proteins that mediate sister chromatid tethering reactions require Scc2, Scc4 for chromatin association and Eco1 ...
Rudra, Soumya
core   +1 more source

The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box [PDF]

, 2017
A dynamic multi-protein assembly known as the replisome is responsible for DNA synthesis in eukaryotic cells. In yeast, the hub protein Ctf4 bridges DNA helicase and DNA polymerase and recruits factors with roles in metabolic processes coupled to DNA ...
Holzer, S, Kilkenny, ML, Mainwaring, J, Pellegrini, L, Simon, AC, Wirthensohn, D   +5 more
core   +1 more source

Spotlight on Warsaw Breakage Syndrome

The Application of Clinical Genetics, 2019
Francesca M Pisani Istituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Naples 80131, ItalyCorrespondence: Francesca M PisaniIstituto di Biochimica e Biologia Cellulare, Consiglio Nazionale delle Ricerche, Via P.
Pisani FM
doaj  

SMC1 coordinates DNA double-strand break repair pathways [PDF]

, 2017
The SMC1/SMC3 heterodimer acts in sister chromatid cohesion, and recent data indicate a function in DNA double-strand break repair (DSBR). Since this role of SMC proteins has remained largely elusive, we explored interactions between SMC1 and the ...
Fäsi, Margaret, Jessberger, Rolf, Schär, Primo   +2 more
core  

DNA damage provokes cohesin sumoylation in Saccharomyces cerevisiae

, 2010
Cohesin tethers sister chromatids together from their creation during S-phase until their separation at the metaphase to anaphase transition. Cohesion is essential for correct segregation and therefore genomic stability.
McAleenan, Alexandra Susan Jane, McAleenan, Alexandra Susan Jane   +1 more
core   +1 more source

Case report: The evolving phenotype of ESCO2 spectrum disorder in a 15-year-old Malaysian child

Frontiers in Genetics
ESCO2 spectrum disorder is an autosomal recessive developmental disorder characterized by growth retardation, symmetrical mesomelic limb malformation, and distinctive facies with microcephaly, with a wide phenotypic continuum that ranges from Roberts ...
Sok-Kun Tae, Sok-Kun Tae, Mazlan RA, Meow-Keong Thong, Meow-Keong Thong   +4 more
doaj   +1 more source

HPV E6/E7‐Induced Acetylation of a Peptide Encoded by a Long Non‐Coding RNA Inhibits Ferroptosis to Promote the Malignancy of Cervical Cancer

Advanced Science
Although a fraction of functional peptides concealed within long non‐coding RNAs (lncRNAs) is identified, it remains unclear whether lncRNA‐encoded peptides are involved in the malignancy of cervical cancer (CC).
Xiaoyu Qi, Jing Zhou, Xinyue Wang, Yan Shen, Yuxun Cao, Liangzi Jiang, Miaomiao Shen, Haoran Zhang, Tianjiao Wang, Pengjun Wei, Ruoqi Xu, Yue Yang, Xiangya Ding, Cong Wang, Xuemei Jia, Qin Yan, Wan Li, Chun Lu   +17 more
doaj   +1 more source

Identification of candidate genes related to hybrid sterility by genomic structural variation and transcriptome analyses in cattle-yak

Journal of Dairy Science
: Hybrids between closely related but genetically incompatible species are often inviable or sterile. Cattle-yak, an interspecific hybrid of yak and cattle, exhibits male-specific sterility, which limits the fixation of its desired traits and prevents ...
Rui-Dong Wan, Xue Gao, Guo-Wen Wang, Shi-Xin Wu, Qi-Lin Yang, Yi-Wen Zhang, Qi-En Yang   +6 more
doaj   +1 more source

More to cohesin than meets the eye: complex diversity for fine-tuning of function [PDF]

, 2017
Recent years have witnessed a dramatic expansion in our understanding of gene control. It is now widely appreciated that the spatial organization of the genome and the manner in which genes and regulatory elements are embedded therein has a critical role
Hadjur, S, Pezic, D, Weeks, SL
core