Results 181 to 190 of about 6,803 (208)

Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion

Science, 2008
Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork–associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast.
Philip East, Frank Uhlmann
exaly   +4 more sources

A Molecular Determinant for the Establishment of Sister Chromatid Cohesion

Science, 2008
Chromosome segregation, transcriptional regulation, and repair of DNA double-strand breaks require the cohesin protein complex. Cohesin holds the replicated chromosomes (sister chromatids) together to mediate sister chromatid cohesion. The mechanism of how cohesion is established is unknown.
Vincent Guacci, Itay Onn
exaly   +4 more sources

Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion

Nature Genetics, 2005
Roberts syndrome is an autosomal recessive disorder characterized by craniofacial anomalies, tetraphocomelia and loss of cohesion at heterochromatic regions of centromeres and the Y chromosome. We identified mutations in a new human gene, ESCO2, associated with Roberts syndrome in 15 kindreds.
Itaru Yanagihara, Hϋlya Kayserili, Ethylin Wang Jabs   +2 more
exaly   +5 more sources

Establishment of Sister Chromatid Cohesion During Chromosome Replication

Seibutsu Butsuri
Yasuto Murayama
semanticscholar   +2 more sources

S-phase and DNA damage activated establishment of sister chromatid cohesion--importance for DNA repair.

Experimental Cell Research, 2010
By holding sister chromatids together from the moment of their formation until their separation at anaphase, the multi subunit protein complex Cohesin guarantees correct chromosome segregation. This S-phase established chromatid cohesion is also essential for repair of DNA double strand breaks (DSB) in postreplicative cells. In addition, Cohesin has to
Camilla Sjögren, L. Ström
semanticscholar   +3 more sources

Faculty Opinions recommendation of Division of Labor between PCNA Loaders in DNA Replication and Sister Chromatid Cohesion Establishment.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2021
D. Dawson
semanticscholar   +2 more sources

Coupling of initiation of DNA replication and establishment of sister chromatid cohesion in Xenopus egg extracts

The FASEB Journal, 2009
Sister chromatid cohesion, which is mediated by a multi‐protein complex cohesin, is established during S‐phase. Recent studies have clarified that a cohesin ring concatenates sister DNA molecules, and that the cohesion is established during S‐phase through acetylation of cohesin subunit.
H. Takisawa, Hiroshi Tanaka
semanticscholar   +2 more sources

Faculty Opinions recommendation of Establishment of sister chromatid cohesion at the S. cerevisiae replication fork.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2006
F. Urnov
semanticscholar   +3 more sources

An indirect test for a role of the synaptonemal complex in the establishment of sister chromatid cohesiveness

Chromosoma, 1979
The meiotic behavior of a special maize trisome was quantitatively observed at pachytene, metaphase I, anaphase I, prophase II, metaphase II and anaphase II. The data obtained are consistent with (but do not prove) the model that sister chromatid cohesiveness at anaphase I may be established during pachytene synapsis of the chromosome regions involved.
openaire   +1 more source

Coupling of sister chromatid cohesion establishment to DNA replication in Saccharomyces Cerevisiae

2017
Sister chromatids are tethered together by the cohesin ring complex from S phase to the onset of anaphase, ensuring faithful chromosome segregation. Defects in sister chromatid cohesion result in premature sister chromatid separation and chromosome loss, which may lead to aneuploidy and chromosome instability (CIN), as commonly seen in solid tumors ...
openaire   +1 more source