Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1. [PDF]
J Biol Chem, 2016 Protein acetylation is a prevalent posttranslational modification that is regulated by diverse acetyltransferase enzymes. Although histone acetyltransferases (HATs) have been well characterized both structurally and mechanistically, far less is known about non-histone acetyltransferase enzymes.
Rivera-Colón Y +4 more
europepmc +7 more sources
A matter of choice: the establishment of sister chromatid cohesion. [PDF]
EMBO Rep, 2009 Sister chromatid cohesion is the basis for the recognition of chromosomal DNA replication products for their bipolar segregation in mitosis. Fundamental to sister chromatid cohesion is the ring-shaped cohesin complex, which is loaded onto chromosomes long before the initiation of DNA replication and is thought to hold replicated sister chromatids ...
Uhlmann F.
europepmc +5 more sources
An Smc3 acetylation cycle is essential for establishment of sister chromatid cohesion. [PDF]
Mol Cell, 2010 Sister chromatid cohesion is thought to involve entrapment of sister DNAs by a tripartite ring composed of the cohesin subunits Smc1, Smc3, and Scc1. Establishment of cohesion during S phase depends on acetylation of Smc3's nucleotide-binding domain (NBD) by the Eco1 acetyl transferase.
Beckouët F +8 more
europepmc +5 more sources
Symmetric control of sister chromatid cohesion establishment
Nucleic Acids Research, 2023 Besides entrapping sister chromatids, cohesin drives other high-order chromosomal structural dynamics like looping, compartmentalization and condensation.
Jiaxin Zhang +14 more
semanticscholar +3 more sources
Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication
Molecular CellConcomitant with DNA replication, the ring-shaped cohesin complex encircles both newly synthesized sister chromatids, enabling their faithful segregation during cell divisions.
Masashi Minamino, J. Diffley, F. Uhlmann
semanticscholar +2 more sources
PCNA promotes context-specific sister chromatid cohesion establishment separate from that of chromatin condensation [PDF]
Cell Cycle, 2020 Cellular genomes undergo various structural changes that include cis tethering (the tethering together of two loci within a single DNA molecule), which promotes chromosome condensation and transcriptional activation, and trans tethering (the tethering ...
Caitlin M. Zuilkoski, R. Skibbens
semanticscholar +3 more sources
eLife, 2017 Bre1, a conserved E3 ubiquitin ligase in Saccharomyces cerevisiae, together with its interacting partner Lge1, are responsible for histone H2B monoubiquitination, which regulates transcription, DNA replication, and DNA damage response and repair ...
Wei Zhang +3 more
doaj +2 more sources
The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair. [PDF]
PLoS Genetics, 2010 The DNA replication process represents a source of DNA stress that causes potentially spontaneous genome damage. This effect might be strengthened by mutations in crucial replication factors, requiring the activation of DNA damage checkpoints to enable ...
Naoki Takahashi +9 more
doaj +6 more sources
SWITCH1 (SWI1): a novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis. [PDF]
Genes & Development, 2001 We have characterized a new gene, SWI1, involved in sister chromatid cohesion during both male and female meiosis in Arabidopsis thaliana. A first allele, swi1.1, was obtained as a T-DNA tagged mutant and was described previously as abnormal exclusively ...
Raphael Mercier +7 more
semanticscholar +4 more sources
A replication fork determinant for the establishment of sister chromatid cohesion
Cell, 2023 Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister chromatids. Cohesion establishment requires acetylation of conserved cohesin lysine residues by Eco1 acetyltransferase. Here, we explore how cohesin acetylation is linked to DNA replication.
Masashi Minamino +4 more
semanticscholar +3 more sources