Reduced sister chromatid cohesion acts as a tumor penetrance modifier.
PLoS Genetics, 2022 Sister chromatid cohesion (SCC) is an important process in chromosome segregation. ESCO2 is essential for establishment of SCC and is often deleted/altered in human cancers.
Jun Wang +9 more
doaj +2 more sources
A Novel Role for α-Importins and Akirin in Establishment of Meiotic Sister Chromatid Cohesion in Caenorhabditis elegans [PDF]
Genetics, 2018 During meiotic prophase I, sister chromatid cohesion is established in a way that supports the assembly of the synaptonemal complex (SC). The SC connects homologous chromosomes, directing meiotic recombination to create crossovers.
R. Bowman +3 more
semanticscholar +3 more sources
PCNA controls establishment of sister chromatid cohesion during S phase. [PDF]
Molecular Cell, 2006 Accurate segregation of the genetic material during cell division requires that sister chromatids are kept together by cohesion proteins until anaphase, when the chromatids become separated and distributed to the two daughter cells. Studies in yeast revealed that chromatid cohesion is essential for viability and is triggered by the conserved protein ...
George‐Lucian Moldovan +2 more
semanticscholar +4 more sources
An extrinsic motor directs chromatin loop formation by cohesin [PDF]
The EMBO JournalThe ring-shaped cohesin complex topologically entraps two DNA molecules to establish sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with wide-ranging implications for gene regulation, and cohesin is thought to achieve ...
Thomas M Guérin +4 more
doaj +2 more sources
Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. [PDF]
Molecular Cell, 2006 Two identical sister copies of eukaryotic chromosomes are synthesized during S phase. To facilitate their recognition as pairs for segregation in mitosis, sister chromatids are held together from their synthesis onward by the chromosomal cohesin complex. Replication fork progression is thought to be coupled to establishment of sister chromatid cohesion,
Armelle Lengronne +6 more
semanticscholar +3 more sources
A SUMO-Dependent Step during Establishment of Sister Chromatid Cohesion [PDF]
Current Biology, 2012 Cohesin is a protein complex that ties sister DNA molecules from the time of DNA replication until the metaphase to anaphase transition. Current models propose that the association of the Smc1, Smc3, and Scc1/Mcd1 subunits creates a ring-shaped structure that entraps the two sister DNAs.
Seba Almedawar +4 more
semanticscholar +4 more sources
Division of Labor between PCNA Loaders in DNA Replication and Sister Chromatid Cohesion Establishment [PDF]
Molecular Cell, 2020 Concomitant with DNA replication, the chromosomal cohesin complex establishes cohesion between newly replicated sister chromatids. Several replication-fork-associated "cohesion establishment factors," including the multifunctional Ctf18-RFC complex, aid this process in as yet unknown ways.
Hon Wing Liu +5 more
semanticscholar +3 more sources
The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks
Cells, 2021 The cohesin complex facilitates faithful chromosome segregation by pairing the sister chromatids after DNA replication until mitosis. In addition, cohesin contributes to proficient and error-free DNA replication.
Janne J. M. van Schie, Job de Lange
doaj +1 more source
Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism [PDF]
The EMBO Journal, 2001 During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism.
Koichi Tanaka +3 more
semanticscholar +3 more sources
Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2014 High fidelity chromosome segregation during mitosis requires that cells identify the products of DNA replication during S-phase and then maintain that identity until anaphase onset.
Kevin Tong, Robert V Skibbens
doaj +1 more source