Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. [PDF]
PLoS Genetics, 2018 Establishment of sister chromatid cohesion is coupled to DNA replication, but the underlying molecular mechanisms are incompletely understood. DDX11 (also named ChlR1) is a super-family 2 Fe-S cluster-containing DNA helicase implicated in Warsaw breakage
Giuseppe Cortone +8 more
doaj +1 more source
S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit
mBio, 2022 During DNA replication, the newly created sister chromatids are held together until their separation at anaphase. The cohesin complex is in charge of creating and maintaining sister chromatid cohesion (SCC) in all eukaryotes.
Karan Choudhary +6 more
doaj +1 more source
Chromosome segregation in plant meiosis [PDF]
, 2014 Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating
De Storme, Nico +4 more
core +7 more sources
Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2. [PDF]
PLoS Genetics, 2019 Cohesin acetyltransferases ESCO1 and ESCO2 play a vital role in establishing sister chromatid cohesion. How ESCO1 and ESCO2 are controlled in a DNA replication-coupled manner remains unclear in higher eukaryotes. Here we show a critical role of CUL4-RING
Haitao Sun +7 more
doaj +1 more source
Integrating Sister Chromatid Cohesion Establishment to DNA Replication
Genes, 2022 The intersection through which two fundamental processes meet provides a unique vantage point from which to view cellular regulation. On the one hand, DNA replication is at the heart of cell division, generating duplicate chromosomes that allow each ...
Caitlin M. Zuilkoski, R. Skibbens
semanticscholar +1 more source
Chl1 DNA helicase regulates Scc2 deposition specifically during DNA-replication in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2013 The conserved family of cohesin proteins that mediate sister chromatid cohesion requires Scc2, Scc4 for chromatin-association and Eco1/Ctf7 for conversion to a tethering competent state.
Soumya Rudra, Robert V Skibbens
doaj +1 more source
Functional Coupling between DNA Replication and Sister Chromatid Cohesion Establishment
International Journal of Molecular Sciences, 2021 Several lines of evidence suggest the existence in the eukaryotic cells of a tight, yet largely unexplored, connection between DNA replication and sister chromatid cohesion.
A. Boavida +3 more
semanticscholar +1 more source
The ctf13-30/CTF13 Genomic Haploinsufficiency Modifier Screen Identifies the Yeast Chromatin Remodeling Complex RSC, Which Is Required for the Establishment of Sister Chromatid Cohesion [PDF]
Molecular and Cellular Biology, 2004 The budding yeast centromere-kinetochore complex ensures high-fidelity chromosome segregation in mitosis and meiosis by mediating the attachment and movement of chromosomes along spindle microtubules. To identify new genes and pathways whose function impinges on chromosome transmission, we developed a genomic haploinsufficiency modifier screen and used
K. Baetz +4 more
semanticscholar +3 more sources
Chromosome Organization in Early Meiotic Prophase
Frontiers in Cell and Developmental Biology, 2021 One of the most fascinating aspects of meiosis is the extensive reorganization of the genome at the prophase of the first meiotic division (prophase I). The first steps of this reorganization are observed with the establishment of an axis structure, that
Corinne Grey, Bernard de Massy
doaj +1 more source
Evidence that replication fork components catalyze establishment of cohesion between sister chromatids [PDF]
Proceedings of the National Academy of Sciences, 2001 Accurate chromosome segregation requires that replicated sister chromatids are held together until anaphase, when their “cohesion” is dissolved, and they are pulled to opposite spindle poles by microtubules. Establishment of new cohesion between sister chromatids in the next cell cycle is coincident with replication fork passage.
D R, Carson, M F, Christman
openaire +2 more sources