Separase prevents genomic instability by controlling replication fork speed [PDF]
, 2016 Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco +11 more
core +6 more sources
Cohesin rings devoid of Scc3 and Pds5 maintain their stable association with the DNA. [PDF]
PLoS Genetics, 2012 Cohesin is a protein complex that forms a ring around sister chromatids thus holding them together. The ring is composed of three proteins: Smc1, Smc3 and Scc1. The roles of three additional proteins that associate with the ring, Scc3, Pds5 and Wpl1, are
Irina Kulemzina +9 more
doaj +1 more source
Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition. [PDF]
PLoS ONE, 2017 Chl1 DNA helicase promotes sister chromatid cohesion and associates with both the cohesion establishment acetyltransferase Eco1/Ctf7 and the DNA polymerase processivity factor PCNA that supports Eco1/Ctf7 function.
Donglai Shen, Robert V Skibbens
doaj +1 more source
Intersection Between the Regulators of Sister Chromatid Cohesion Establishment and Maintenance in Budding Yeast Indicates a Multi-Step Mechanism [PDF]
Cell Cycle, 2006 Sister chromatid cohesion is established during S phase and maintained until anaphase. The cohesin complex (Mcd1p/Scc1p, Smc1p, Smc3p Irr1p/Scc3p in budding yeast) serves a structural role as it is required at all times when cohesion exists. Pds5p colocalizes temporally and spatially with cohesin on chromosomes but is thought to serve as a regulator of
Daniel Noble +5 more
semanticscholar +3 more sources
Sequential primed kinases create a damage-responsive phosphodegron on Eco1. [PDF]
, 2013 Sister-chromatid cohesion is established during S phase when Eco1 acetylates cohesin. In budding yeast, Eco1 activity falls after S phase due to Cdk1-dependent phosphorylation, which triggers ubiquitination by SCF(Cdc4).
Diedrich, Jolene K +4 more
core +1 more source
Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors [PDF]
, 2023 The chromosomal cohesin complex establishes sister chromatid cohesion during S phase, which forms the basis for faithful segregation of DNA replication products during cell divisions.
Bouchoux, Céline +5 more
core +2 more sources
A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]
, 2019 Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan +4 more
core +2 more sources
In Favor of Establishment: Regulation of Chromatid Cohesion in Plants
Frontiers in Plant Science, 2017 In eukaryotic organisms, the correct regulation of sister chromatid cohesion, whereby sister chromatids are paired and held together, is essential for accurate segregation of the sister chromatids and homologous chromosomes into daughter cells during ...
Pablo Bolaños-Villegas +4 more
doaj +1 more source
Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion [PDF]
, 2019 Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, lead to double strand breaks (DSBs), which are preferentially repaired by sister-chromatid recombination (SCR).
Aguilera López, Andrés +2 more
core +1 more source
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2010 D. Dawson
semanticscholar +3 more sources