Results 61 to 70 of about 6,803 (208)

Sister chromatid cohesion halts DNA loop expansion

bioRxiv, 2023
Eukaryotic genomes are folded into DNA loops mediated by structural maintenance of chromosomes (SMC) complexes such as cohesin, condensin and Smc5/6. This organization regulates different DNA-related processes along the cell cycle such as transcription ...
Nathalie Bastié, Christophe Chapard, Sanae Nejmi, Henri Mboumba, A. Thierry, Frédéric Beckouët, R. Koszul   +6 more
semanticscholar   +1 more source

Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation. [PDF]

PLoS Genetics, 2014
Chromosome segregation errors in human oocytes are the leading cause of birth defects, and the risk of aneuploid pregnancy increases dramatically as women age. Accurate segregation demands that sister chromatid cohesion remain intact for decades in human
Katherine A Weng, Charlotte A Jeffreys, Sharon E Bickel   +2 more
doaj   +1 more source

A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae. [PDF]

, 2016
Errors segregating homologous chromosomes during meiosis result in aneuploid gametes and are the largest contributing factor to birth defects and spontaneous abortions in humans.
Burgess, Sean M, Chu, Daniel B
core   +3 more sources

ATRX: From Chromatin Remodeling to Disease. [PDF]

Genesis
ABSTRACT Chromatin remodeling proteins are evolutionarily conserved factors involved in a wide range of biological processes. In this review, we describe ATRX, a chromatin remodeling protein belonging to the SWI/SNF2 family. Its association with different protein complexes, and its roles in embryonic development, sexual differentiation, as well as ...
Magaña-Acosta M, Valadez-Graham V.
europepmc   +2 more sources

Mapping Topoisomerase IV Binding and Activity Sites on the E. coli Genome. [PDF]

PLoS Genetics, 2016
Catenation links between sister chromatids are formed progressively during DNA replication and are involved in the establishment of sister chromatid cohesion.
Hafez El Sayyed, Ludovic Le Chat, Elise Lebailly, Elise Vickridge, Carine Pages, Francois Cornet, Marco Cosentino Lagomarsino, Olivier Espéli   +7 more
doaj   +1 more source

The histone methyltransferase NSD3 contributes to sister chromatid cohesion and to cohesin loading at mitotic exit.

Journal of Cell Science, 2023
Sister chromatid cohesion is a multi-step process implemented throughout the cell cycle to ensure the correct transmission of chromosomes to daughter cells. While cohesion establishment and mitotic cohesion dissolution have been extensively explored, the
G. Eot-Houllier, L. Magnaghi-Jaulin, Gaëlle Bourgine, F. Smagulova, R. Giet, E. Watrin, C. Jaulin   +6 more
semanticscholar   +1 more source

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
A Chavez, A De Muyt, A Hochwagen, A Hochwagen, A Irmisch, A McAleenan, A Schwacha, A Sourirajan, A Svetlanov, AC Chan, AJ Wood, AL Marston, Alex D. Herbert, Alice Copsey, Andreas Hochwagen, Andrew Chi-ho Chan, B Rockmill, BH Lee, C Buhler, C Tapia-Alveal, DM Sheedy, E Ampatzidou, EA Andrews, EA Outwin, ER Hoffmann, Eva Hoffmann, F Osman, FZ Watts, G De Piccoli, G Vader, GA Cromie, GR Smith, GV Borner, H Murakami, Hannah G. Blitzblau, HB Lindroos, HG Blitzblau, HG Blitzblau, HG Yu, HG Yu, I Lilienthal, J Gregan, J Matos, J Matos, J Palecek, J Pan, J Torres-Rosell, J Zalevsky, JA Carballo, JA Downs, JK Holloway, JM Murray, JR Mullen, JR Mullen, JS Bickel, K Nishimura, K Zakharyevich, K Zakharyevich, KA Henderson, KP Kim, KP Kohl, KT Nishant, L Jessop, L Jessop, L Newnham, L Wu, L Xu, LE Berchowitz, LE Hang, LJ Gaskell, Louise Newnham, M Bermudez-Lopez, M Xaver, MA Roy, Michael Lichten, MJ Neale, MN Boddy, MS McMahill, N Hunter, N Hunter, N Wu, Neil Hunter, NK Kolas, O Yildiz, P Jordan, Philip W. Jordan, PR Potts, PR Potts, Prakash Arumugam, RK Clyne, S Agarwal, S Chu, S Farmer, S Gray, S Panizza, S Pebernard, S Wehrkamp-Richter, SB Buonomo, SD Oh, SD Oh, Shangming Tang, SL Andersen, Sonya Newcombe, Stephen Gray, T de los Santos, T Snowden, T Wechsler, TM Carlile, TS Kitajima, V Kaliraman, WM Fricke, X Zhao, Y Blat, YH Chen, YH Chen, Zhaobo Li   +115 more
core   +3 more sources

SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? [PDF]

, 1999
The assembly of mitotic chromosomes is a fundamental cellular event that ensures the faithful segregation of genetic information during cell division. It involves two processes that are, in principle, mechanistically distinct.
Hirano, T.
core   +1 more source

Sensitivity of cohesin–chromatin association to high-salt treatment corroborates non-topological mode of loop extrusion

Epigenetics & Chromatin, 2021
Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions through the process
Arkadiy K. Golov, Anastasia V. Golova, Alexey A. Gavrilov, Sergey V. Razin   +3 more
doaj   +1 more source

Dynamic molecular linkers of the genome: the first decade of SMC proteins [PDF]

, 2005
Structural maintenance of chromosomes (SMC) proteins are chromosomal ATPases, highly conserved from bacteria to humans, that play fundamental roles in many aspects of higher-order chromosome organization and dynamics.
Hirano, T., Losada, A.
core   +1 more source