Results 71 to 80 of about 6,803 (208)
Research progress of acidic nucleoplasmic DNA-binding protein 1 [PDF]
Jichu yixue yu linchuang, 2021 Acidic nucleoplasmic DNA-binding protein 1 (And-1/WDHD1) as a natural chimerical protein, is characterized by containing the WD-repeat and the HMG-box motif families.
CUI Ya-ting, GOU Wen-feng, WEI Hui-qiang, YU Jiang, HOU Wen-bin, LI Yi-liang
doaj
Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms
bioRxiv, 2022 Cohesin connects CTCF binding sites and other genomic loci in cis to form chromatin loops, and replicated DNA molecules in trans to mediate sister chromatid cohesion.
Kota Nagasaka +10 more
semanticscholar +1 more source
Sequential Loading of Cohesin Subunits during the First Meiotic Prophase of Grasshoppers [PDF]
, 2007 A previous version of this article appeared as an Early Online Release on January 2, 2007 (doi:10.1371/journal.pgen.0030028.eor).The cohesin complexes play a key role in chromosome segregation during both mitosis and meiosis.
Valdeolmillos, Ana M. +10 more
core +1 more source
MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion
eLife, 2018 DNA replication transforms cohesin rings dynamically associated with chromatin into the cohesive form to establish sister-chromatid cohesion. Here, we show that, in human cells, cohesin loading onto chromosomes during early S phase requires the ...
Ge Zheng +3 more
doaj +1 more source
An ever-changing landscape in Roberts syndrome biology: Implications for macromolecular damage.
PLoS Genetics, 2020 Roberts syndrome (RBS) is a rare developmental disorder that can include craniofacial abnormalities, limb malformations, missing digits, intellectual disabilities, stillbirth, and early mortality.
Michael G Mfarej, Robert V Skibbens
doaj +1 more source
The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion and repair [PDF]
, 2002 The first draft of the human genome sequence was reported a year ago. It may be a good time to remind ourselves that the genetic information encoded in the ∼3000-Mb sequence is stored not only in the public or private databases but also in the tiny space
Hirano, T.
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D
Advanced Science, EarlyView.CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley +1 more source
ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner
BMC Cancer, 2023 Background The establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) is involved in the development of multiple malignancies. However, its role in hypopharyngeal carcinoma (HPC) progression remains uncharacterized.
Juan Hu +12 more
doaj +1 more source
bioRxiv, 2022 The cohesin complex regulates higher order chromosome architecture through maintaining sister chromatid cohesion and folding chromatin by active DNA loop extrusion.
J. J. van Schie +14 more
semanticscholar +1 more source