Results 81 to 90 of about 6,803 (208)

“Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines [PDF]

, 2014
The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes.
Bartkova, Baumann, Baxter, Baxter, Baxter, Bermejo, Bester, Branzei, Branzei, Brill, Burrell, Bzymek, Cejka, Champoux, Champoux, Chan, Chan, Chang, Chu, Crisona, Cuylen, Cuylen, Delbrück, Di Micco, Dominguez-Sola, Ekholm-Reed, Farcas, Fernandez, Gandhi, Gangloff, Gerlich, Germann, Giet, Goodwin, Gorgoulis, Halazonetis, Hardy, Hawkins, Hendzel, Hiasa, Hiasa, Hiasa, Hills, Hirano, Hirano, Hirano, Holm, Hsu, Jonathan Baxter, Kato, Kato, Khodursky, Khodursky, Kimura, Kimura, Kitamura, Koshland, Kreuzer, Kueng, Lavoie, Leman, Lucas, Mantiero, Maresca, Marston, Martinez-Robles, Matos, McClendon, McClintock, McGlynn, McGuffee, Mullen, Naughton, Neelsen, Newport, Oliveira, Ono, Paulson, Peter, Postow, Rattner, Rybenkov, Rybenkov, Sakaguchi, Samejima, Schoeffler, Schvartzman, Shamu, Shintomi, Spruck, Stuchinskaya, Sullivan, Sundin, Sundin, Suski, Symington, Szakal, Tedeschi, Temime-Smaali, Toledo, Vologodskii, Vos, Wang, Wang, Wang, Watson, Watson, Wei, Wilkins, Zechiedrich, Zechiedrich   +110 more
core   +1 more source

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, EarlyView.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

Cancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi, Rubaiat E. Tabassum, Kouji Hirota   +2 more
wiley   +1 more source

Epigenetic regulation of Mash1 expression [PDF]

, 2010
Mash1 is a proneural gene important for specifying the neural fate. The Mash1 locus undergoes specific epigenetic changes in ES cells following neural induction.
Beretta, Chiara, Beretta, Chiara
core   +1 more source

Induction of Synthetic Apomixis in Two Sorghum Hybrids Enables Seed Yield and Genotype Preservation Over Multiple Generations

Plant Biotechnology Journal, EarlyView.
ABSTRACT Induction of apomixis, or clonal reproduction through seed, could economise commercial hybrid seed production and enable smallholder farmers to save and sow hybrid seed. Here, we demonstrate the synthetic induction of apomixis in two sorghum hybrids and show that the clonal hybrid seed can be maintained across multiple seed generations.
Marissa K. Simon, Li Yuan, Ping Che, Kevin Day, Todd Jones, Ian D. Godwin, Anna M. G. Koltunow, Marc C. Albertsen   +7 more
wiley   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, Volume 13, Issue 8, 9 February 2026.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Repression of transcription at DNA breaks requires cohesin throughout interphase and prevents genome instability [PDF]

, 2019
Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells.
Benstead-Hume, Graeme, Downs, Jessica A, Hopkins, Suzanna R, Jeggo, Penny A, Meisenberg, Cornelia, Pearl, Frances M G, Pinder, Sarah I, Wooller, Sarah K   +7 more
core   +2 more sources

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division

BioEssays, Volume 48, Issue 1, January 2026.
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo, Hradini Konthalapalli, Claudio Alfieri, Jonathon Pines   +3 more
wiley   +1 more source

Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes

eLife, 2014
We show that multiple, functionally specialized cohesin complexes mediate the establishment and two-step release of sister chromatid cohesion that underlies the production of haploid gametes. In C.
Aaron F Severson, Barbara J Meyer
doaj   +1 more source

Communication between distinct subunit interfaces of the cohesin complex promotes its topological entrapment of DNA. [PDF]

, 2019
Cohesin mediates higher order chromosome structure. Its biological activities require topological entrapment of DNA within a lumen(s) formed by cohesin subunits.
Chatterjee, Fiona, Guacci, Vincent, Koshland, Douglas, Robison, Brett   +3 more
core   +1 more source