Results 111 to 120 of about 381,897 (302)

Consciência nacional, democratização e conflito político: semelhanças e diferenças entre Guiné-Bissau e Moçambique [PDF]

, 2010
Este trabalho debate a consciência nacional, a democratização e o conflito político vivenciados pela sociedade e pelo Estado guineense e moçambicano durante o processo de construção do Estado Nacional, bem como suas implicações nas recentes experiências ...
Texeira, Ricardino
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

CÓDIGOS DECIMONÓNICOS Y DERECHOS FUNDAMENTALES

Teoría & Derecho, 2020
El problema de la relación entre Códigos y Derechos Fundamentales puede ser visto a la luz de la llamada «constitución material» El Código es complemento de la Constitución material liberal: se puede hablar de la existencia de un par funcional ...
Ángel M. López y López
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Liberalismo, derechos humanos y desarrollo en un orden político democrático [PDF]

, 2014
El objetivo del presente documento plantea que al garantizar los derechos humanos se crean condiciones para el florecimiento de la ciudadanía, misma que es indispensable para fomentar el desarrollo de una nación con un Estado democrático de derecho.
ESPEJEL MENA, JAIME, ESPEJEL MENA, JAIME, FLORES VEGA, MISAEL, FLORES VEGA, MISAEL   +3 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Ideologia liberal e construção do Estado do Brasil

Anais do Museu Paulista: História e Cultura Material, 1981
This paper inquires into the limits of the actuation of the principies of North-American liberalism in the process of building up the Brazilian State during the last century. These principies are opposed to the pressures exercised by forces of the counter-revolutionary ideology, among them the “haitinism”, a term used to convey the increasing dread of ...
openaire   +2 more sources

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

El castigo de los obispos liberales después del Trienio: Pedro González Vallejo, obispo de Mallorca (1819-1825) [PDF]

, 2011
Durante el Trienio Liberal (1820-1823) no fueron fáciles las relaciones entre la Iglesia y el Estado, y el nombramiento de los obispos agudizó el problema. En este artículo, después de describir el proyecto liberal de formar un equipo episcopal adicto al
Barrio Gozalo, Maximiliano
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source