Results 221 to 230 of about 1,021,999 (290)

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Anthropogenic Barriers Limit Fish Access to Essential Habitats in the Amazon in the Face of Climate Change. [PDF]

Glob Chang Biol
Yofukuji KY, Fabrin TMC, Stabile BHM, Agostinho AA, Jézéquel C, Batista-Silva VF, Esser LF, Ferreira JHD, Ré R, Tedesco PA, Azevedo JC, Bailly D.   +11 more
europepmc   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

The Role of the Naples Prognostic Score in the Evaluation of SVG Patency Following CABG Surgery. [PDF]

Arq Bras Cardiol
Gürsoy MO, Güneş H.
europepmc   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

<i>De <i>N</i>ovo</i>-Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV-2 Main Protease. [PDF]

J Chem Inf Model
Lima TE, Moreira EG, Coêlho DF, Cruz CHB, Dhalia R, Leite BHS, Xavier LS, Illana MP, Wallau GL, Viana IFT, Lins RD.   +10 more
europepmc   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

A new species of <i>Oecetis</i> McLachlan, 1877 (Trichoptera, Leptoceridae) and new distributional records of Trichoptera in the eastern Amazon. [PDF]

Zookeys
Quinteiro FB, Costa AM, Saldanha G, Moura L, Assunção OT, Juen L.   +5 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Analysis of DNA methyltransferase 3 alpha expression during respiratory syncytial virus strain A infection. [PDF]

Sci Rep
Becker AL, Borges SG, Pinheiro LGR, Nascimento Freitas D, Duarte L, Nunes E, Cassão G, Poppe J, da Silva RP, Castro MS, Fernandes KA, Andrade CF, de Oliveira Espinel J, de Rezende Rodovalho V, Vinolo MAR, Stein RT, de Souza APD.   +16 more
europepmc   +1 more source