Results 221 to 230 of about 1,021,196 (293)

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

A bio-optical database for the remote sensing of water quality in BRAZil coAstal and inland waters (BRAZA). [PDF]

Sci Data
Maciel DA, Barbosa CCF, de Moraes Novo EML, Wanderley RLDN, Bacellar P, Baia LB, Bernini H, Chasles RG, Ciotti A, Fassoni-Andrade A, Júnior RF, Lima T, Lopes F, Marinho RR, Martinelli A, Martins VS, Miranda M, Cesar GM, da Motta Marques D, Noernberg MA, da Silva FHO, Pacheco F, Paulino RS, Pereira Filho W, Pimenta Dos Santos JC, Sander de Carvalho LA, Sousa da Silva M, Tavares MH, Ummus M, de Matos Valério A, Souza Filho PWME, Watanabe FSY, Zem RC.   +32 more
europepmc   +1 more source

Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody‐Mediated Thrombotic Disorders

Advanced Science, EarlyView.
A microfluidic electrochemical biosensor enables sensitive and specific detection of antibodies associated with vaccine‐induced immune thrombotic thrombocytopenia (VITT) and heparin‐induced thrombocytopenia (HIT). The platform uses two antigen targets— platelet factor 4 (PF4) and cross‐linked‐PF4 (c‐PF4)—and microliter volumes of patient sera to ...
Diana F. Cedillo‐Alcantar, Adam Kanack, Seonhwa Lee, Alan M. Gonzalez‐Suarez, Kihak Gwon, Emily Mauch, Thi Thanh‐Qui Nguyen, Anand Padmanabhan, Alexander Revzin   +8 more
wiley   +1 more source

Screening for CKD in undiagnosed populations with diabetes and hypertension: lessons from the SEARCH study. [PDF]

J Bras Nefrol
Moraes TP, Moura AF, Sposito AC, Lopes FPPL, Quadros Junior ARA, Gadelha V, Eliaschewitz FG, Bertoluci MC, Samaan F, Montenegro C, Rego T, Pecoits-Filho R.   +11 more
europepmc   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Case series: effects of platelet-rich plasma (PRP) on the recovery of bilateral muscle injuries after removal of semitendinosus and gracilis grafts in bilateral anterior cruciate ligament (ACL) reconstruction. [PDF]

J Surg Case Rep
De Castro Pochini A, Bueno AC, Mattos RAC, Ejnisman B, Cohen M.   +4 more
europepmc   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

Climate change and challenges for health surveillance in the Oropouche emergency. [PDF]

Rev Bras Enferm
Thomas CL, Soares KKS, Cola JP, Maciel ELN.   +3 more
europepmc   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Correction: Extent and diversity of recognized Indigenous and community lands: Cases from Northern and Western Europe. [PDF]

Ambio
Bebbington A, Shrestha Sangat S, Golden Kroner RE, Mustonen T.   +3 more
europepmc   +1 more source