Results 231 to 240 of about 1,021,999 (290)

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Transcriptomic, proteomic and biochemical comparison of luminescent and non-luminescent Keroplatinae larvae (Diptera: Keroplatidae). [PDF]

Insect Mol Biol
Silva JR, Pelentir GF, Amaral DT, Stevani C, Viviani VR.   +4 more
europepmc   +1 more source

A iconografia nos manuais escolares do Estado Novo [PDF]

, 2009
Mesquita, Cristina, Mesquita, Elza, Ribeiro, Maria do Céu   +2 more
core  

WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement

Advanced Science, EarlyView.
This review synthesizes emerging insights into WUSCHEL (WUS) as a central regulator of plant stem cell fate beyond Arabidopsis, highlighting its roles in regeneration, somatic embryogenesis (SE), and stress adaptation across crops. It explores how WUS‐centered regulatory networks, genome editing, and AI‐guided strategies can be leveraged for precise ...
Zishan Ahmad, Muthusamy Ramakrishnan, Rajeev K. Varshney, Anwar Shahzad, Shamsur Rehman, Bijaya Pant, Qiang Wei   +6 more
wiley   +1 more source

Quinazolinones as Bioisosteres of Naphthoquinones: A Path to Potent <i>Hs</i>DHODH Inhibitors with Optimized Properties. [PDF]

ACS Med Chem Lett
Godoi BF, Bueno JD, Silva WJL, da Purificação AD, Leite PIP, Dos Santos T, Freitas M, Silva DG, Silva TC, de Moraes J, Freitas CS, Mattos M, Souza TML, Martin BA, Lopez RFV, Nonato MC, Andrade CH, Emery FS.   +17 more
europepmc   +1 more source

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Brazilian consensus- and evidence-based recommendations in the diagnosis and treatment of pancreatic exocrine insufficiency in patients after digestive surgeries. Position paper of six brazilian medical societies of surgery. [PDF]

Arq Bras Cir Dig
Montagnini AL, Bernardo WM, Kassab P, Quireze Junior C, Oliveira CVC, Diniz AL, Pinheiro RN, Oliveira AF, Portari Filho P, Ravanini GAG, Forones NM, Pertille MFK, Valezi AC, Dantas ACB, Marzinotto MAN, Figueira ER, Jukemura J, Ribeiro Junior U, Herman P.   +18 more
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Study of Nutrition, Health, and Food Security of Indigenous Peoples in the State of Alagoas, Brazil (ENSSAIA): Methodological Aspects. [PDF]

Food Sci Nutr
Dos Santos TR, de Oliveira VC, Cardoso MA, de Assunção ML, da Silva AH, Vieira RCDS, Barbosa LB, Maynart WHDC, Dos Santos EA, Ferreira HDS.   +9 more
europepmc   +1 more source