Results 121 to 130 of about 269,608 (328)

Infecções urinárias causadas por Trichosporon spp. em pacientes graves internados em unidade de terapia intensiva

Revista Brasileira de Terapia Intensiva, 2015
RESUMOObjetivo:Avaliar a incidência de infecções do trato urinário por Trichosporon spp. em uma unidade de terapia intensiva.Métodos:Estudo descritivo observacional realizado em uma unidade de terapia intensiva no período de 2007 a 2009. Foram analisados
Maria das Graças Silva Mattede, Cláudio Piras, Kelly Dematte Silva Mattede, Aline Trugilho Ferrari, Lorena Simões Baldotto, Michel Silvestre Zouain Assbu   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Evaluacion economica: implementacion nuevo terminal interprovincial de buses para la Ciudad de Talca [PDF]

, 2004
68 p.De acuerdo al ultimo Censo de Chile de 2002, la cantidad de habitantes de la Región del Maule ha experimentado en la ultima década un aumento cercano al 17%, crecimiento que no se ha traducido en las mejoras de infraestructura vial requeridas por su
Saens Navarrete, Rodrigo (Prof. Guia), Troncoso Arteaga, Esteban   +1 more
core  

VI Jornada de Cuidados Paliativos do INCA

Revista Brasileira de Cancerologia, 2016
Resumos escolhidos para publicação. Nessa edição, os títulos foram: Fatores Associados à Sobrevida de Pacientes com Câncer Avançado em Cuidados Paliativos; Relação do Estado Nutricional e da Resposta Inflamatória Sistêmica com a Sobrevida de Pacientes ...
Instituto Nacional de Câncer José Alencar Gomes da Silva
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Doença crítica crônica: estamos salvando ou criando vítimas?

Revista Brasileira de Terapia Intensiva
RESUMO Os avanços tecnológicos que permitem dar suporte às disfunções de órgãos levaram a um aumento nas taxas de sobrevivência para a maioria dos pacientes críticos. Alguns destes pacientes sobrevivem à condição crítica inicial, porém continuam a sofrer
Sergio Henrique Loss, Diego Silva Leite Nunes, Oellen Stuani Franzosi, Gabriela Soranço Salazar, Cassiano Teixeira, Silvia Regina Rios Vieira   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The tadpole of Physalaemus fernandezae (Anura: Leptodactylidae) [PDF]

, 2006
This paper describes the external and buccopharyngeal morphology, chondrocranium and cranial muscles in tadpoles of Physalaemus fernandezae. The data are compared with those for other species of Physalaemus to improve the diagnosis of the “species group”
Alcalde, Leandro, Cajade, Rodrigo, Natale, Guillermo Sebastian   +2 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source