Results 121 to 130 of about 270,121 (304)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Doença crítica crônica: estamos salvando ou criando vítimas?

Revista Brasileira de Terapia Intensiva
RESUMO Os avanços tecnológicos que permitem dar suporte às disfunções de órgãos levaram a um aumento nas taxas de sobrevivência para a maioria dos pacientes críticos. Alguns destes pacientes sobrevivem à condição crítica inicial, porém continuam a sofrer
Sergio Henrique Loss, Diego Silva Leite Nunes, Oellen Stuani Franzosi, Gabriela Soranço Salazar, Cassiano Teixeira, Silvia Regina Rios Vieira   +5 more
doaj   +1 more source

Asistencia integral en cuidados paliativos de pacientes en estado terminal en Colombia

, 2012
Este trabajo de investigación resume los parámetros generales bajo los cuales se presta el servicio de salud en Colombia. Muestra de manera somera los diferentes cambios que el Sistema de Salud en Colombia ha experimentado durante los últimos 60 años y confronta la actualidad de lo que se plantea en dicho Sistema contra la realidad que afrontan muchos ...
Valencia Escobar, Edgar Adrián, Zuluaga Salazar, Lina Yisseth   +1 more
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Necesidades de infraestructura y procesos logísticos de los puertos de Santa Marta y Barranquilla-Colombia para la operación con buques portacontenedores tipo Neopanamax [PDF]

, 2017
Visita Técnica InternacionalSe realizó un comparativo de las condiciones actuales de infraestructura y procesos logísticos de los puertos de Santa Marta y Barranquilla-Colombia, establecidas a través de una revisión en internet, versus las condiciones de
Bustos-Calderón, Deavit Fabián
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Critical health-disease transition in the family: Nursing intervention in the lived experience

Revista Brasileira de Enfermagem
Objective: To analyse the strategies found by families to deal with the situation of critical illness, in their lived experience in a family and in an inpatient context.
Anabela Pereira Mendes
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Efecto de herbicidas post-emergentes aplicados en distintos estados del cultivo de trigo (Triticum aestivum L.)

Semiárida, 2020
Se analizó la respuesta del cultivo de trigo (Triticum aestivum L.) cv. Buck Charrúa a varios herbicidas aplicados en diferentes estadios del cultivo y la eficacia de los mismos sobre el control de malezas.
C. J. Arriaga, H. J. Ronco, R. O. Vidales   +2 more
doaj