Results 41 to 50 of about 16,606 (215)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
El estatuto del ser humano en estado terminal
, 2023 El objeto del presente trabajo es el estatus del ser humano en estado terminal. En principio nadie negaría el estatuto de persona al ser humano en la plenitud de su vida consciente, por tanto, esta cuestión se recrudece especialmente cuando se refiere al
Herrera, Daniel Alejandro
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Principios éticos en la toma de decisiones en pacientes en estado terminal
, 2008 To limit the therapeutic effort is considered an option in terminal patients. We analyse this in an ethical and medical context, and propose an algorhythm which takes into account: the patient and family will and the treating physician medical ...
Zambrano, Mariana +6 more
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Epidemiologia da doença renal crônica terminal no Estado da Paraíba: resgate de cinco anos de terapia renal substitutiva, 2009-2013 [PDF]
, 2015 INTRODUÇÃO: A Doença Renal Crônica (DRC), nosologia de proporções epidêmicas e distribuição mundial, e, que na fase terminal, necessita de TRS para manutenção da vida, desponta na Paraíba como problema de saúde ante os custos e necessidade de assistência
Cariry, Bertrand Saulo Vieira
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Comunicación y apoyo emocional del enfermero al familiar del paciente en estado terminal. Hospital General - Jaén, 2020 [PDF]
, 2023 La investigación tuvo como objetivo: Analizar cómo es la comunicación y el apoyo emocional del enfermero al familiar del paciente en estado terminal en el Hospital General I de Jaén. Material y métodos.
Chunga Cruz, Rosita Elvira
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