Results 61 to 70 of about 4,882,386 (282)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Nefrectomía Laparoscópica para Donación Renal.

Revista Guatemalteca de Urología, 2017
El trasplante renal no está al alcance de la gran mayoría de pacientes con enfermedad renal en estado terminal.  El trasplante renal de donador vivo ha venido en aumento para disminuir el periodo de espera de trasplante; el inconveniente es que no está ...
Estuardo Polanco
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Terminal cranes unloading Liberty ships.

, 1944
Terminal cranes unloading Liberty ships loaded with iron ore from North Africa. The open storage area in the foreground had recently been cindered and is now suitable for open storage purposes.
Wilmington Marine Terminal
core   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Terminalidade e espiritualidade: uma reflexão a partir dos Códigos de Ética Médica brasileiros e leitura comparada de alguns países

O Mundo da Saúde, 2009
presente artigo objetiva aprofundar o debate de questões éticas relacionadas ao processo de revisão do Código de Ética Médica Brasileiro, sob o enfoque de duas vertentes: as questões éticas de final de vida e as questões éticas implicadas pela ...
Leo Pessini
doaj  

COGNICIÓN HACIA LA ENFERMEDAD, BIENESTAR ESPIRITUAL Y CALIDAD DE VIDA EN PACIENTES CON CÁNCER EN ESTADO TERMINAL

Acta Colombiana de Psicología, 2011
El objetivo de este estudio fue evaluar la relación de la cognición hacia la enfermedad y el bienestar espiritual con la calidad de vida en 50 pacientes con cáncer en estado terminal de la ciudad de Medellín, Colombia. El diseño del estudio fue exploratorio descriptivo correlacional transversal.
PAYÁN, ENNA CATALINA, VINACCIA, STEFANO, QUICENO, JAPCY MARGARITA   +2 more
openaire   +5 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Estado del arte. Daño hepático crónico en Enfermedad Renal Terminal y Hemodiálisis

Revista CIE
La cirrosis, estadio avanzado de fibrosis hepática, tiene entre sus principales causas el consumo de alcohol, obesidad e infecciones virales. En la última década, esta condición ha sido ampliamente estudiada en pacientes con enfermedad renal crónica (ERC) en hemodiálisis (HD), una población con factores de riesgo similares para infecciones.
Clara Cristina Sánchez Rodríguez, Manuel Sharif Santos Salem, Elvia Donají Sánchez Solís   +2 more
openaire   +1 more source