Results 81 to 90 of about 270,351 (261)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Acquiring Word-Meaning Mappings for Natural Language Interfaces
, 2011 This paper focuses on a system, WOLFIE (WOrd Learning From Interpreted Examples), that acquires a semantic lexicon from a corpus of sentences paired with semantic representations.
Thompson, C.
core +1 more source
Alois Alzheimer and vascular brain disease: Arteriosclerotic atrophy of the brain. [PDF]
, 2015 Alois Alzheimer is best known for his description of neurofibrillary changes in brain neurons of a demented patient, identifying a novel disease, soon named after him by Kraepelin.
Engelhardt, Eliasz, Grinberg, Lea T
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Recomendación para la Atención Ético-Médica del Paciente Terminal
Medicina, 2002 <p><strong>(Aprobada en Sesión del 18 de abril de 2002)</strong></p><p><em>Pautas para el Manejo Ético-Médico del Paciente en Estado Terminal.</em></p><p>En la actualidad, los avances tecnológicos en ...
Fernando Sánchez Torres
doaj
Identification of an osteocalcin isoform in fish with a large acidic prodomain [PDF]
, 2014 Osteocalcin is a small, secreted bone protein whose gene consists of four exons. In the course of analyzing the structure of fish osteocalcin genes, we recently found that the spotted green pufferfish has two possible exon 2 structures, one of 15 bp and ...
Amores +30 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Heteroreceptor complexes and their allosteric receptor-receptor interactions in the central nervous system. Focus on examples from Dopamine D2 and Serotonin 5-HT1a receptors [PDF]
, 2018 GPCR interacting proteins (specially β- arrestin) and their receptor-protein interactions are also covered but their interactions with the allosteric receptor-receptor interactions in heteroreceptor complexes remain to be elucidated.
Corrales Ferro, Fidel
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Avaliação do risco nutricional em pacientes oncológicos graves: revisão sistemática
Revista Brasileira de Terapia Intensiva, 2015 RESUMOObjetivo:Revisar sistematicamente os principais métodos para avaliação do risco nutricional utilizados em pacientes oncológicos graves e apresentar aqueles que melhor avaliam os riscos e preveem desfechos clínicos relevantes neste grupo de ...
Ana Valéria Gonçalves Fruchtenicht +6 more
doaj +1 more source